CENPK and PCBD2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		CENPK	PCBD2
Description		centromere protein K	pterin-4 alpha-carbinolamine dehydratase 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol	Mitochondrion
	Molecular Function	Protein Binding	Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Kinetochore Assembly	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of DNA-templated Transcription
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subcortical volume (MOSTest) ( 32665545)	Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951 28552196) Type 2 diabetes ( 24509480)
Interacting Genes		10 interacting genes: AP1G2 HSPB1 MRFAP1L1 PCBD2 PEX14 RTN4IP1 SOX6 TRIM55 TRIM63 WASHC3	41 interacting genes: AATF APP ASCC2 BCAS2 BRF1 C1D CDC5L CENPK CERS3 CHAF1A FBXO7 GTF2E1 GUCD1 HES4 IRF2BP1 KCNIP3 KLC3 LGALS14 MAGEA11 MAGEA6 MED21 MED30 MED4 MED7 MET MRFAP1 PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SPG21 SSX3 SSX5 STAT3 TAL2 TGIF2LY USP2-AS1 XBP1 ZZZ3
Entrez ID		64105	84105
HPRD ID		13323	17824
Ensembl ID		ENSG00000123219	ENSG00000132570
Uniprot IDs		D6RHD3 D6RJF0 Q9BS16	Q9H0N5
PDB IDs		7PB4 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	4C45
Enriched GO Terms of Interacting Partners?		Contractile Muscle Fiber	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Preinitiation Complex Assembly Transcription Coactivator Activity Core Mediator Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Mediator Complex Negative Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly RNA Polymerase II Preinitiation Complex Assembly Nuclear Vitamin D Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Coregulator Activity Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Initiation U2-type Catalytic Step 2 Spliceosome Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Interleukin-6 Production Regulation Of Interleukin-1 Beta Production Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Metabolic Process Transcription Corepressor Activity Ubiquitin Ligase Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Interleukin-1 Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Stem Cell Population Maintenance
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