MCCC2 and LINC00624

Number of citations of the paper that reports this interaction (PubMedID 36252997)
50

Data Source:
BioGRID (unspecified method)

		MCCC2	LINC00624
Description		methylcrotonyl-CoA carboxylase subunit 2	long intergenic non-protein coding RNA 624
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Methylcrotonoyl-CoA Carboxylase Complex
	Molecular Function	Nucleotide Binding Methylcrotonoyl-CoA Carboxylase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	L-leucine Catabolic Process Branched-chain Amino Acid Catabolic Process Coenzyme A Metabolic Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Branched-chain amino acid catabolism 3-Methylcrotonyl-CoA carboxylase deficiency
Drugs		Biotin
Diseases		3-Methylcrotonylglycinuria; 3-Methylcrotonyl-CoA carboxylase deficiency
GWAS		Chromosomal aberration frequency (chromatid type) ( 31586183) Metabolite levels ( 23823483)	Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) End-stage kidney disease ( 31178898) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		4 interacting genes: CFTR HSPB2 LINC00624 OGT	38 interacting genes: ACTA1 ACTC1 ADAR ALB CCT2 CCT4 CPNE3 DDX42 DDX5 EIF2AK2 FUBP3 G6PD H2BC18 HDAC6 HNRNPL HNRNPM HNRNPU HRNR ILF3 MCCC1 MCCC2 NONO PARP1 PTBP1 PTBP2 PTBP3 SERBP1 SFPQ SND1 SRRT STAU1 STAU2 TRIM28 TUBA1B TUBA1C UBAP2L YBX3 ZNF354C
Entrez ID		64087	100289211
HPRD ID		01952
Ensembl ID		ENSG00000131844	ENSG00000278811
Uniprot IDs		A0A140VK29 A0A804HHS4 Q9HCC0
PDB IDs		8J4Z 8J73 8J78 8J7D 8J99 8JAK 8JAW 8JXL 8JXM 8JXN 8K2V 8XL6 8XL7 8XL8
Enriched GO Terms of Interacting Partners?		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Somatic Muscle Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Regulation Of Transcription By Glucose ATPase-coupled Inorganic Anion Transmembrane Transporter Activity NSL Complex Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	RNA Binding RNA Localization Nucleic Acid Binding Double-stranded RNA Binding MRNA Processing MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Viral Genome Replication Negative Regulation Of Metabolic Process Dendritic Transport Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Splicing Regulation Of Viral Life Cycle RNA Processing Cytoskeleton-dependent Intracellular Transport Alternative MRNA Splicing, Via Spliceosome Regulation Of Viral Process RNA Metabolic Process Cell Body Nucleus Axo-dendritic Transport Paraspeckles Regulation Of Macromolecule Biosynthetic Process Intracellular MRNA Localization Extracellular Exosome Regulation Of RNA Splicing Methylcrotonoyl-CoA Carboxylase Complex Methylcrotonoyl-CoA Carboxylase Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Pre-mRNA Binding Cytoplasm Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Dendritic Transport Of Messenger Ribonucleoprotein Complex Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Chemical Stress Negative Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Transport Along Microtubule Binding Of Sperm To Zona Pellucida Mesenchyme Migration ScaRNA Localization To Cajal Body
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