MCCC2

Description		methylcrotonyl-CoA carboxylase subunit 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Methylcrotonoyl-CoA Carboxylase Complex
	Molecular Function	Nucleotide Binding Methylcrotonoyl-CoA Carboxylase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	L-leucine Catabolic Process Branched-chain Amino Acid Catabolic Process Coenzyme A Metabolic Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Branched-chain amino acid catabolism 3-Methylcrotonyl-CoA carboxylase deficiency
Drugs		Biotin
Diseases		3-Methylcrotonylglycinuria; 3-Methylcrotonyl-CoA carboxylase deficiency
GWAS		Chromosomal aberration frequency (chromatid type) ( 31586183) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: CFTR HSPB2 LINC00624 OGT
Entrez ID		64087
HPRD ID		01952
Ensembl ID		ENSG00000131844
Uniprot IDs		A0A140VK29 A0A804HHS4 Q9HCC0
PDB IDs		8J4Z 8J73 8J78 8J7D 8J99 8JAK 8JAW 8JXL 8JXM 8JXN 8K2V 8XL6 8XL7 8XL8
Enriched GO Terms of Interacting Partners?		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Membrane Hyperpolarization Somatic Muscle Development Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Regulation Of Transcription By Glucose ATPase-coupled Inorganic Anion Transmembrane Transporter Activity NSL Complex Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
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