FIRRM and P4HA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FIRRM	P4HA3
Description		FIGNL1 interacting regulator of recombination and mitosis	prolyl 4-hydroxylase subunit alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Midbody Spindle Midzone	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding Protein Kinase Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Interstrand Cross-link Repair Regulation Of Protein Kinase Activity	Collagen Fibril Organization
Pathways		Resolution of Sister Chromatid Cohesion Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination	Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS			Hippocampal atrophy ( 25625606)
Interacting Genes		5 interacting genes: APP DMC1 FIGNL1 P4HA3 RAD51	49 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A FIRRM GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZC3H12A
Entrez ID		55732	283208
HPRD ID		07694	16413
Ensembl ID		ENSG00000000460	ENSG00000149380
Uniprot IDs		A0A1B0GUP7 A0A1B0GV14 B4E0A9 Q9NSG2	Q7Z4N8
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Strand Exchange Activity Meiotic Nuclear Division DNA Strand Invasion DNA Recombinase Assembly Nuclear Division Double-strand Break Repair Involved In Meiotic Recombination Lateral Element ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Reciprocal Meiotic Recombination Nuclear Chromosome ATP-dependent Activity, Acting On DNA Homologous Recombination Meiosis I Condensed Nuclear Chromosome Male Meiotic Nuclear Division Chromosome Organization Involved In Meiotic Cell Cycle Response To Radiation Meiosis I Cell Cycle Process Reproductive Process Cellular Response To Ionizing Radiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cellular Response To Stress Response To Glucoside Regulation Of Double-strand Break Repair Via Homologous Recombination Site Of Double-strand Break Single-stranded DNA Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Meiotic Cell Cycle Mitotic Recombination-dependent Replication Fork Processing Double-stranded DNA Binding Presynaptic Intermediate Filament Cytoskeleton Double-strand Break Repair Via Homologous Recombination Perinuclear Region Of Cytoplasm Regulation Of DNA Recombination Recombinational Repair Response To Ionizing Radiation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium	Protein Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Acetylation Gamma-tubulin Binding
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