FIRRM and DMC1

Number of citations of the paper that reports this interaction (PubMedID 29608566)
71

Data Source:
BioGRID (two hybrid, two hybrid)

		FIRRM	DMC1
Description		FIGNL1 interacting regulator of recombination and mitosis	DNA meiotic recombinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Midbody Spindle Midzone	Chromosome, Telomeric Region Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Chromosome Site Of Double-strand Break
	Molecular Function	Protein Binding Protein Kinase Binding	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Identical Protein Binding Catalytic Activity, Acting On DNA ATP-dependent DNA Damage Sensor Activity
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Interstrand Cross-link Repair Regulation Of Protein Kinase Activity	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Ovarian Follicle Development Oocyte Maturation DNA Metabolic Process DNA Repair Mitotic Recombination Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiosis I Gamete Generation Spermatogenesis Spermatid Development Female Gamete Generation DNA Strand Invasion Oogenesis Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Resolution of Sister Chromatid Cohesion Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination	Meiotic recombination Meiotic recombination
Drugs			Imidazole
Diseases
GWAS			Gamma glutamyl transferase levels ( 29403010) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Menopause (age at onset) ( 26414677) Sleep duration ( 30846698)
Interacting Genes		5 interacting genes: APP DMC1 FIGNL1 P4HA3 RAD51	20 interacting genes: BRCA2 FIGNL1 FIRRM GORASP2 KCTD17 LNX1 MCPH1 MSH4 NIF3L1 PIAS2 PICK1 PSMA3 RAD51 RAD51AP1 RAD54B RPA1 SDCBP SDCBP2 TRIM23 UBE2I
Entrez ID		55732	11144
HPRD ID		07694	04099
Ensembl ID		ENSG00000000460	ENSG00000100206
Uniprot IDs		A0A1B0GUP7 A0A1B0GV14 B4E0A9 Q9NSG2	Q14565
PDB IDs			1V5W 2ZJB 4HYY 6R3P 7C98 7C99 7C9C 7CGY 8QQE 8R2G
Enriched GO Terms of Interacting Partners?		DNA Strand Exchange Activity Meiotic Nuclear Division DNA Strand Invasion DNA Recombinase Assembly Nuclear Division Double-strand Break Repair Involved In Meiotic Recombination Lateral Element ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Reciprocal Meiotic Recombination Nuclear Chromosome ATP-dependent Activity, Acting On DNA Homologous Recombination Meiosis I Condensed Nuclear Chromosome Male Meiotic Nuclear Division Chromosome Organization Involved In Meiotic Cell Cycle Response To Radiation Meiosis I Cell Cycle Process Reproductive Process Cellular Response To Ionizing Radiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cellular Response To Stress Response To Glucoside Regulation Of Double-strand Break Repair Via Homologous Recombination Site Of Double-strand Break Single-stranded DNA Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Meiotic Cell Cycle Mitotic Recombination-dependent Replication Fork Processing Double-stranded DNA Binding Presynaptic Intermediate Filament Cytoskeleton Double-strand Break Repair Via Homologous Recombination Perinuclear Region Of Cytoplasm Regulation Of DNA Recombination Recombinational Repair Response To Ionizing Radiation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium	Recombinational Repair Lateral Element Double-strand Break Repair Via Homologous Recombination Response To Ionizing Radiation DNA Recombination Mitotic Recombination-dependent Replication Fork Processing DNA Repair Mitotic Recombination Cellular Response To Ionizing Radiation Cellular Response To Stress Reciprocal Meiotic Recombination Double-strand Break Repair Nuclear Chromosome Single-stranded DNA Binding PML Body Identical Protein Binding Condensed Chromosome Meiotic Cell Cycle Homologous Recombination DNA Metabolic Process Interstrand Cross-link Repair Nuclear Ubiquitin Ligase Complex DNA Damage Response Condensed Nuclear Chromosome Cellular Response To Radiation Chromosome, Telomeric Region Reproductive Process Meiotic Nuclear Division Macromolecule Metabolic Process Telomere Maintenance Via Recombination Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Division ATP-dependent DNA Damage Sensor Activity Telomere Maintenance SUMO Transferase Activity Response To Stress Regulation Of DNA Damage Checkpoint Synaptonemal Complex Nucleoplasm Telomere Organization Response To X-ray Double-stranded DNA Binding Mismatch Repair Regulation Of DNA Recombination Telomere Maintenance Via Telomere Lengthening Chromosome Organization Nucleus Regulation Of Double-strand Break Repair Chromosome
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