DMC1 and FIRRM

Number of citations of the paper that reports this interaction (PubMedID 29608566)
71

Data Source:
BioGRID (two hybrid, two hybrid)

		DMC1	FIRRM
Description		DNA meiotic recombinase 1	FIGNL1 interacting regulator of recombination and mitosis
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Chromosome Site Of Double-strand Break	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Midbody Spindle Midzone
	Molecular Function	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Identical Protein Binding Catalytic Activity, Acting On DNA ATP-dependent DNA Damage Sensor Activity	Protein Binding Protein Kinase Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Ovarian Follicle Development Oocyte Maturation DNA Metabolic Process DNA Repair Mitotic Recombination Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiosis I Gamete Generation Spermatogenesis Spermatid Development Female Gamete Generation DNA Strand Invasion Oogenesis Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Double-strand Break Repair Involved In Meiotic Recombination	Mitotic Cell Cycle Chromosome Segregation Interstrand Cross-link Repair Regulation Of Protein Kinase Activity
Pathways		Meiotic recombination Meiotic recombination	Resolution of Sister Chromatid Cohesion Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination
Drugs		Imidazole
Diseases
GWAS		Gamma glutamyl transferase levels ( 29403010) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Menopause (age at onset) ( 26414677) Sleep duration ( 30846698)
Interacting Genes		20 interacting genes: BRCA2 FIGNL1 FIRRM GORASP2 KCTD17 LNX1 MCPH1 MSH4 NIF3L1 PIAS2 PICK1 PSMA3 RAD51 RAD51AP1 RAD54B RPA1 SDCBP SDCBP2 TRIM23 UBE2I	5 interacting genes: APP DMC1 FIGNL1 P4HA3 RAD51
Entrez ID		11144	55732
HPRD ID		04099	07694
Ensembl ID		ENSG00000100206	ENSG00000000460
Uniprot IDs		Q14565	A0A1B0GUP7 A0A1B0GV14 B4E0A9 Q9NSG2
PDB IDs		1V5W 2ZJB 4HYY 6R3P 7C98 7C99 7C9C 7CGY 8QQE 8R2G
Enriched GO Terms of Interacting Partners?		Recombinational Repair Lateral Element Double-strand Break Repair Via Homologous Recombination Response To Ionizing Radiation DNA Recombination Mitotic Recombination-dependent Replication Fork Processing DNA Repair Mitotic Recombination Cellular Response To Ionizing Radiation Cellular Response To Stress Reciprocal Meiotic Recombination Double-strand Break Repair Nuclear Chromosome Single-stranded DNA Binding PML Body Identical Protein Binding Condensed Chromosome Meiotic Cell Cycle Homologous Recombination DNA Metabolic Process Interstrand Cross-link Repair Nuclear Ubiquitin Ligase Complex DNA Damage Response Condensed Nuclear Chromosome Cellular Response To Radiation Chromosome, Telomeric Region Reproductive Process Meiotic Nuclear Division Macromolecule Metabolic Process Telomere Maintenance Via Recombination Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Division ATP-dependent DNA Damage Sensor Activity Telomere Maintenance SUMO Transferase Activity Response To Stress Regulation Of DNA Damage Checkpoint Synaptonemal Complex Nucleoplasm Telomere Organization Response To X-ray Double-stranded DNA Binding Mismatch Repair Regulation Of DNA Recombination Telomere Maintenance Via Telomere Lengthening Chromosome Organization Nucleus Regulation Of Double-strand Break Repair Chromosome	DNA Strand Exchange Activity Meiotic Nuclear Division DNA Strand Invasion DNA Recombinase Assembly Nuclear Division Double-strand Break Repair Involved In Meiotic Recombination Lateral Element ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Reciprocal Meiotic Recombination Nuclear Chromosome ATP-dependent Activity, Acting On DNA Homologous Recombination Meiosis I Condensed Nuclear Chromosome Male Meiotic Nuclear Division Chromosome Organization Involved In Meiotic Cell Cycle Response To Radiation Meiosis I Cell Cycle Process Reproductive Process Cellular Response To Ionizing Radiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cellular Response To Stress Response To Glucoside Regulation Of Double-strand Break Repair Via Homologous Recombination Site Of Double-strand Break Single-stranded DNA Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Meiotic Cell Cycle Mitotic Recombination-dependent Replication Fork Processing Double-stranded DNA Binding Presynaptic Intermediate Filament Cytoskeleton Double-strand Break Repair Via Homologous Recombination Perinuclear Region Of Cytoplasm Regulation Of DNA Recombination Recombinational Repair Response To Ionizing Radiation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium
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