PARD6G and RBM14

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		PARD6G	RBM14
Description		par-6 family cell polarity regulator gamma	RNA binding motif protein 14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Tight Junction Anchoring Junction PAR Polarity Complex	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Nuclear Speck Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleic Acid Binding Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Splicing Factor Binding
	Biological Process	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Regulation Of Cellular Localization	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Immune System Process Apoptotic Process Gastrulation Response To Hormone Gene Expression Innate Immune Response Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Centriole Replication Centriole Assembly Regulation Of Response To DNA Integrity Checkpoint Signaling
Pathways		Tight junction interactions	RUNX2 regulates bone development
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Interacting Genes		11 interacting genes: AKAP9 CASK CDC42 DMRTB1 KIFAP3 NDEL1 PARD3 PRKCI PRKCZ RAC1 RBM14	118 interacting genes: AKAP9 ATN1 CASK CEBPA CEP55 CFTR CRLF3 CTBP1 DDX17 DDX6 DMRTB1 DYNLT1 EP300 FMR1 FXR2 HOMER3 ITCH KHDRBS2 KIFAP3 KLC4 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NCOA6 NDEL1 NEDD4 NFKBID NR3C1 PARD6G PARP1 PCBP1 PRKCI QKI RBM10 RBM5 RPA2 RUNX1 RUNX2 SLAIN1 SS18 SYT1 TARBP2 TRIM55 TRIM63 UBE2I UFSP1 XRCC5 YAP1 YWHAE
Entrez ID		84552	10432
HPRD ID		10138	11485
Ensembl ID		ENSG00000178184	ENSG00000239306
Uniprot IDs		Q9BYG4	A0A0S2Z4Z0 A0A0S2Z567 A0A0S2Z5V2 Q96PK6
PDB IDs			2DNP
Enriched GO Terms of Interacting Partners?		PAR Polarity Complex Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Microtubule-based Process Establishment Of Cell Polarity Cytoskeleton Organization Centrosome Localization Organelle Organization Tight Junction Cell-cell Junction Organization Cell-cell Junction Cell Leading Edge G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Axon Hillock Cellular Localization Glutamatergic Synapse Thioesterase Binding Establishment Of Organelle Localization Neuron Projection Morphogenesis Cell Projection Morphogenesis Organelle Transport Along Microtubule Intracellular Protein Localization Microtubule Organizing Center Positive Regulation Of Ruffle Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Projection Organization Bicellular Tight Junction Cerebral Cortex Radially Oriented Cell Migration GTP-dependent Protein Binding Regulation Of Cell Adhesion Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Organelle Localization Establishment Of Epithelial Cell Polarity Transport Along Microtubule Phagocytosis, Engulfment Cell Junction Organization Regulation Of Ruffle Assembly Cerebral Cortex Cell Migration Microtubule Nucleation Cell Cortex Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cytoskeleton Organization	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process MRNA Destabilization Regulation Of Metabolic Process Positive Regulation Of MRNA Catabolic Process RNA Destabilization Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Translation Regulation Of RNA Stability Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Blood Vessel Endothelial Cell Migration
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