PARD6G and PARD3

Number of citations of the paper that reports this interaction (PubMedID 12459187)
0

Data Source:
HPRD (in vitro, in vivo)

		PARD6G	PARD3
Description		par-6 family cell polarity regulator gamma	par-3 family cell polarity regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Tight Junction Anchoring Junction PAR Polarity Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Membrane Apical Plasma Membrane Cell Junction Internode Region Of Axon Apical Junction Complex Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Regulation Of Cellular Localization	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Adhesion Establishment Or Maintenance Of Cell Polarity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Intracellular Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Cell Differentiation Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Establishment Of Centrosome Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways		Tight junction interactions	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)
Interacting Genes		11 interacting genes: AKAP9 CASK CDC42 DMRTB1 KIFAP3 NDEL1 PARD3 PRKCI PRKCZ RAC1 RBM14	31 interacting genes: ACE2 CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN UBC YWHAB YWHAG YWHAH YWHAZ
Entrez ID		84552	56288
HPRD ID		10138	05994
Ensembl ID		ENSG00000178184	ENSG00000148498
Uniprot IDs		Q9BYG4	Q8TEW0
PDB IDs			2KOM
Enriched GO Terms of Interacting Partners?		PAR Polarity Complex Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Microtubule-based Process Establishment Of Cell Polarity Cytoskeleton Organization Centrosome Localization Organelle Organization Tight Junction Cell-cell Junction Organization Cell-cell Junction Cell Leading Edge G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Axon Hillock Cellular Localization Glutamatergic Synapse Thioesterase Binding Establishment Of Organelle Localization Neuron Projection Morphogenesis Cell Projection Morphogenesis Organelle Transport Along Microtubule Intracellular Protein Localization Microtubule Organizing Center Positive Regulation Of Ruffle Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Projection Organization Bicellular Tight Junction Cerebral Cortex Radially Oriented Cell Migration GTP-dependent Protein Binding Regulation Of Cell Adhesion Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Organelle Localization Establishment Of Epithelial Cell Polarity Transport Along Microtubule Phagocytosis, Engulfment Cell Junction Organization Regulation Of Ruffle Assembly Cerebral Cortex Cell Migration Microtubule Nucleation Cell Cortex Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cytoskeleton Organization	Heteromeric SMAD Protein Complex Intracellular Signal Transduction I-SMAD Binding Tight Junction PAR Polarity Complex Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity SMAD Protein Complex Establishment Or Maintenance Of Apical/basal Cell Polarity SMAD Protein Signal Transduction Cell-cell Junction Organization Cytosol Protein-containing Complex Establishment Or Maintenance Of Cell Polarity Mesonephric Tubule Development Mesonephric Epithelium Development Identical Protein Binding Cytoplasm Regulation Of Cellular Component Organization Bicellular Tight Junction Tube Development Kidney Epithelium Development Positive Regulation Of Cell Differentiation Endoderm Development Regulation Of Protein Localization Anchoring Junction Ureteric Bud Development Co-SMAD Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Localization Primary MiRNA Processing Golgi Localization Cell Junction Organization Intracellular Protein Localization Extracellular Exosome Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transport Homomeric SMAD Protein Complex Cardiac Conduction System Development Regulation Of Cell Differentiation Intracellular Signaling Cassette Regulation Of Signaling Regulation Of Cell Communication Regulation Of Transport Signal Transduction Embryonic Pattern Specification Epithelium Development Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Localization Transcription Regulator Complex Response To Monosaccharide
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