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PCIF1 and PDX1
Number of citations of the paper that reports this interaction (PMID
17126328
)
3
Data Source:
HPRD
(in vivo, in vitro)
PCIF1
PDX1
Gene Name
PDX1 C-terminal inhibiting factor 1
pancreatic and duodenal homeobox 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Microtubule Cytoskeleton
Intercellular Bridge
Nucleus
Cytosol
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity
Transcription Factor Binding
Protein Complex Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Phosphatase Activity
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Liver Development
Type B Pancreatic Cell Differentiation
Glucose Metabolic Process
Generation Of Precursor Metabolites And Energy
Transcription From RNA Polymerase II Promoter
Smoothened Signaling Pathway
Nitric Oxide Mediated Signal Transduction
Central Nervous System Development
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Response To Wounding
Organ Morphogenesis
Response To Iron(II) Ion
Response To Chlorate
Organ Senescence
Positive Regulation Of Cell Death
Morphogenesis Of Embryonic Epithelium
Insulin Secretion
Exocrine Pancreas Development
Endocrine Pancreas Development
Organ Regeneration
Positive Regulation Of Insulin Secretion
Response To Vitamin
Response To Cytokine
Response To Nicotine
Response To Drug
Glucose Homeostasis
Response To Leucine
Positive Regulation Of DNA Binding
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Digestive Tract Development
Stem Cell Differentiation
Response To Glucocorticoid
Detection Of Glucose
Transdifferentiation
Response To Fatty Acid
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways
Regulation of beta-cell development
Regulation of gene expression in early pancreatic precursor cells
Regulation of gene expression in beta cells
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Fasting glucose-related traits (interaction with BMI) (
22581228
)
Protein-Protein Interactions
3 interactors:
APP
PDX1
POLR2A
13 interactors:
ATF3
CREB1
IAPP
MAFA
NEUROD1
PBX1
PCIF1
PRKDC
SLC2A2
SPOP
TCF3
XRCC5
XRCC6
Entrez ID
63935
3651
HPRD ID
12779
02843
Ensembl ID
ENSG00000100982
ENSG00000139515
Uniprot IDs
B7Z5U5
Q9H4Z3
P52945
PDB IDs
2JX8
Enriched GO Terms of Interacting Partners
?
Transcription, RNA-templated
Synaptic Growth At Neuromuscular Junction
Organ Senescence
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Collateral Sprouting In Absence Of Injury
Detection Of Glucose
Regulation Of Binding
Response To Chlorate
Stem Cell Differentiation
Collateral Sprouting
Axon Midline Choice Point Recognition
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Response To Iron(II) Ion
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Axon Choice Point Recognition
Response To Leucine
MRNA Processing
Neuron Remodeling
Exocrine Pancreas Development
Regulation Of Cellular Ketone Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Secretion By Cell
MRNA Metabolic Process
Transdifferentiation
RNA Processing
Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate
Nitric Oxide Mediated Signal Transduction
Regulation Of Acyl-CoA Biosynthetic Process
Secretion
Cellular Copper Ion Homeostasis
RNA Metabolic Process
Response To Wounding
Copper Ion Homeostasis
Suckling Behavior
Negative Regulation Of Cell Differentiation
Type B Pancreatic Cell Differentiation
Enteroendocrine Cell Differentiation
Cell Differentiation
Positive Regulation Of Metabolic Process
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Response To Stress
Gene Expression
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Neuron Maturation
MRNA Polyadenylation
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Chemical Homeostasis
7-methylguanosine MRNA Capping
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Double-strand Break Repair Via Nonhomologous End Joining
Organ Development
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Hyperosmotic Salinity Response
Positive Regulation Of Gene Expression
V(D)J Recombination
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Brain Development
Head Development
Cellular Response To X-ray
Endocrine Pancreas Development
Immunoglobulin V(D)J Recombination
System Development
DNA Recombination
Central Nervous System Development
Transcription, DNA-templated
Regulation Of Cell Differentiation
Establishment Of Integrated Proviral Latency
Anterior/posterior Pattern Specification
RNA Biosynthetic Process
Cellular Hyperosmotic Response
Hyperosmotic Salinity Response
Telomere Maintenance
Positive Regulation Of Type I Interferon Production
B Cell Lineage Commitment
Establishment Of Viral Latency
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Salt Stress
Multicellular Organismal Development
Pancreas Development
Anatomical Structure Development
Immune System Development
Regulation Of Neurogenesis
Regulation Of Type I Interferon Production
Nitric Oxide Mediated Signal Transduction
Negative Regulation Of Cellular Metabolic Process
Innate Immune Response
Regulation Of Protein Stability
Immune System Process
Positive Regulation Of Neurogenesis
Regulation Of Cell Development
Positive Regulation Of Cell Differentiation
Response To Ionizing Radiation
Developmental Process
Double-strand Break Repair
Transcription From RNA Polymerase II Promoter
Hyperosmotic Response
Tagcloud
?
ablate
ablated
adenoviral
carry
cycles
ductal
ganciclovir
gcv
implants
intraperitoneal
ip
iv
liposomal
longest
microg
minimal
monitored
panc
pancreatic
pdac
repeated
scid
superior
suppresses
survived
thymidine
tk
toxicity
vectors
Tagcloud (Difference)
?
ablate
ablated
adenoviral
carry
cycles
ductal
ganciclovir
gcv
implants
intraperitoneal
ip
iv
liposomal
longest
microg
minimal
monitored
panc
pancreatic
pdac
repeated
scid
superior
suppresses
survived
thymidine
tk
toxicity
vectors
Tagcloud (Intersection)
?