DUSP21 and GET4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DUSP21	GET4
Description		dual specificity phosphatase 21	guided entry of tail-anchored proteins factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytoskeleton Cilium Membrane Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol BAT3 Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Protein Binding Protein-folding Chaperone Binding Protein Carrier Chaperone
	Biological Process	Flagellated Sperm Motility Peptidyl-tyrosine Dephosphorylation	Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Stability ERAD Pathway Maintenance Of Unfolded Protein Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS			PR interval ( 32439900)
Interacting Genes		33 interacting genes: APP ATP23 BPIFA1 CPNE7 CTBP2 EPHA3 EPHA5 ERBB3 ERBB4 EYA2 FAAP20 GET4 GORASP2 IGF1R KLHL20 KRT33B KRTAP11-1 MAP2K5 MYO15B OIP5 POU4F3 PTK7 RFX6 RGS2 ROR1 ROR2 SUOX TEX11 TOX3 TRAF1 UBQLN2 USP2 ZMAT1	29 interacting genes: AIRIM AKT1 ATP5PD CAPNS1 CDKN1A CEBPA CEP126 DUSP21 EEF1G ENKD1 FBN1 FBXO7 FLYWCH2 GIT2 KAT5 KIFC2 KRTAP9-3 NUP85 PLK1 PRKAB2 PRKCSH PTMS SDCBP SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2
Entrez ID		63904	51608
HPRD ID		06494	12909
Ensembl ID		ENSG00000189037	ENSG00000239857
Uniprot IDs		Q9H596	Q7L5D6
PDB IDs			6AU8 7RU9 7RUA 7RUC
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Kinase Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Neuregulin Receptor Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway GPI-linked Ephrin Receptor Activity Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Coreceptor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Glial Cell Development Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Cellular Developmental Process Insulin Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Neuron Projection Guidance Axon Guidance ERBB2 Signaling Pathway Establishment Of Planar Polarity ATP Binding Epithelial Cell Differentiation Amyloid-beta Complex Apoptotic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Programmed Cell Death Positive Regulation Of Toll Signaling Pathway Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Heart Development Cranial Nerve Development Establishment Of Planar Polarity Involved In Nephron Morphogenesis Insulin-like Growth Factor Receptor Signaling Pathway Wnt-protein Binding Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Sulfite Oxidase Activity Type II Interferon Binding Meiotic Gene Conversion	Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Microtubule Cytoskeleton Organization Involved In Mitosis Establishment Of Mitotic Spindle Orientation Establishment Of Spindle Localization Response To Nutrient Levels Spindle Localization Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Localization To Nucleus Establishment Of Protein Localization To Organelle Carbohydrate Homeostasis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Glucose Homeostasis Protein Localization To Endoplasmic Reticulum Regulation Of Macroautophagy Microtubule-based Process Positive Regulation Of Protein Modification Process
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