PRDM1 and MAD2L1BP

		PRDM1	MAD2L1BP
Description		PR/SET domain 1	MAD2L1 binding protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytoskeleton Nuclear Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Morphogenesis Of A Branching Structure Kidney Development Embryonic Placenta Development Maternal Placenta Development Adaptive Immune Response Immune System Process Heart Valve Development Cardiac Septum Development Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Germ Cell Development Post-embryonic Development Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Aorta Development Regulation Of Cell Population Proliferation Eye Photoreceptor Cell Development Innate Immune Response Cell Fate Commitment Artery Morphogenesis Cellular Developmental Process Regulation Of NK T Cell Differentiation Retinal Bipolar Neuron Differentiation Intestinal Epithelial Cell Development Trophoblast Giant Cell Differentiation Coronary Vasculature Development Sebum Secreting Cell Proliferation	Regulation Of Exit From Mitosis Deactivation Of Mitotic Spindle Assembly Checkpoint
Pathways		Regulation of TP53 Expression STAT3 nuclear events downstream of ALK signaling Specification of primordial germ cells
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 33272962 19838193 28714469 27399966 26502338 23273568 19838195) Systemic sclerosis ( 28314753) Triglyceride levels ( 32203549)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: ATXN1 CFTR H1-1 H3C15 HNF1B IKZF3 IRF4 KDM1A NFIC NFIX PIAS1 TLE1 TLE2 TLE5	18 interacting genes: ANAPC4 CEP126 EEF1A1 HOMEZ IGSF21 KAT5 KRT15 LRIF1 MAD2L1 MAD2L2 NMI PLK1 PTN SETDB1 TP53 TRIP13 ZBTB14 ZNF202
Entrez ID		639	9587
HPRD ID		04572	10065
Ensembl ID		ENSG00000057657	ENSG00000124688
Uniprot IDs		A0A3B3IU23 B4DW27 O75626 Q5T4E8	Q15013
PDB IDs		3DAL	2QYF 6F0X
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Promoter-specific Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Animal Organ Morphogenesis DNA Binding Nucleosome Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Anoikis Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Recombination Positive Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Regulation Of Programmed Cell Death Negative Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity	Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Chromosome Organization Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Nuclear Division Chromosome Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation Negative Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Establishment Of Mitotic Spindle Orientation Negative Regulation Of Cell Cycle Process Microtubule Cytoskeleton Organization Involved In Mitosis Establishment Of Mitotic Spindle Localization Negative Regulation Of Double-strand Break Repair Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Establishment Of Spindle Orientation Regulation Of Nuclear Division Negative Regulation Of Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Recombination Chromosome Organization Establishment Of Spindle Localization Negative Regulation Of Cell Cycle Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus Negative Regulation Of Metabolic Process Negative Regulation Of Ubiquitin Protein Ligase Activity Spindle Localization Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Germ Cell Development Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Transferase Activity Promoter-specific Chromatin Binding Regulation Of Cell Cycle
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