ABHD4 and PLIN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABHD4	PLIN3
Description		abhydrolase domain containing 4, N-acyl phospholipase B	perilipin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Droplet	Cytoplasm Endosome Golgi Apparatus Lipid Droplet Cytosol Endosome Membrane Membrane Transport Vesicle
	Molecular Function	Phosphatidylcholine Lysophospholipase Activity Protein Binding Hydrolase Activity Lysophosphatidic Acid Acyltransferase Activity	Protein Binding Cadherin Binding
	Biological Process	Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling Lipid Homeostasis N-acylphosphatidylethanolamine Metabolic Process	Positive Regulation Of Triglyceride Storage Vesicle-mediated Transport Lipid Storage Cellular Response To Glucose Starvation Lipid Droplet Disassembly
Pathways		Acyl chain remodelling of PE	Triglyceride catabolism Retrograde transport at the Trans-Golgi-Network Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy RHOBTB3 ATPase cycle
Drugs			Idursulfase Galsulfase
Diseases
GWAS		Metabolite levels ( 23823483) Microalbuminuria ( 26631737)	Basal cell carcinoma ( 27539887) Lung cancer in ever smokers ( 28604730) Visceral fat ( 30942860)
Interacting Genes		14 interacting genes: AURKAIP1 BNIP2 CMTM5 COL4A5 CSNK2B DERL1 DGAT2L6 HTATIP2 IGFBP5 INSIG2 PLIN3 RABAC1 REEP5 TK1	33 interacting genes: ABHD4 ABHD5 APP CCNC CEBPA CHMP4B CMTM5 CPD CYBC1 GAD2 HSD17B13 IGF2R LNPK M6PR MAX MIEF1 MYG1 PBX3 PIAS3 PTPN9 RAB9A SFT2D2 SMAD2 SNX1 SNX2 SPART SYNGR1 SYNGR3 SYP TARS2 TBC1D13 TBPL1 TMEM14C
Entrez ID		63874	10226
HPRD ID		12406	04080
Ensembl ID		ENSG00000100439	ENSG00000105355
Uniprot IDs		Q8TB40	A0A140VJN8 O60664
PDB IDs
Enriched GO Terms of Interacting Partners?			Collateral Sprouting In Absence Of Injury Insulin Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Vesicle-mediated Transport Identical Protein Binding Retromer, Tubulation Complex Leptin Receptor Binding Lipid Droplet Trans-Golgi Network Membrane Lamellipodium Morphogenesis Regulation Of Neuronal Synaptic Plasticity Endocytosis Nuclear Envelope Lumen Retromer Complex Binding Transferrin Receptor Binding Regulation Of Synaptic Vesicle Priming Lysophosphatidic Acid Acyltransferase Activity Intracellular Transport Receptor-mediated Endocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Collateral Sprouting Early Endosome To Golgi Transport Neuromuscular Junction Endosome Establishment Of Protein Localization Neuron Projection Terminus Regulation Of Neurotransmitter Uptake Retromer Complex Protein Transport Retrograde Transport, Endosome To Golgi Midbody Abscission Transport Vesicle Cytoplasmic Vesicle Import Into Cell Mitotic Cytokinetic Process
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