XCL1 and CCL26

Number of citations: 0 (PubMedID 28381538)
Data Source: BioGRID (pull down, pull down)

		XCL1	CCL26
Name		X-C motif chemokine ligand 1	C-C motif chemokine ligand 26
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding CX3C Chemokine Receptor Binding Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Killing Of Cells Of Another Organism Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling T Cell Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Eosinophil Chemotaxis Positive Regulation Of Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (q) signalling events	None
GWAS		Blood protein levels ( 30072576 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Metabolite levels ( 23823483 ) Psoriasis ( 34927100 )	Carotid plaque burden ( 28282560 ) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309 )
Novel Interactors		2 novel interactors: FBLN5 TNFSF18	None recorded
Interacting Genes		19 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 KRTAP10-3 PF4 PF4V1 VCAN XCR1	24 interacting genes: APP C3orf52 CCL11 CCL13 CCL17 CCL2 CCL21 CCL28 CCL5 CCL8 CCR1 CCR3 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL9 PAX6 PF4 PF4V1 PPBP XCL1 XCL2
Entrez ID		6375	10344
HPRD ID		02595	05262
Ensembl ID		ENSG00000143184	ENSG00000006606
Uniprot IDs		P47992	Q9Y258
PDB IDs		1J8I 1J9O 2HDM 2JP1 2N54 2NYZ 9AST	1G2S 1G2T
GO Terms Enriched among Interactors		Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine Activity Antimicrobial Humoral Response Chemotaxis Locomotion Leukocyte Chemotaxis Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Migration Granulocyte Migration Cell Motility Killing Of Cells Of Another Organism Extracellular Space Cell Killing Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism CXCR Chemokine Receptor Binding Immune System Process Defense Response Extracellular Region Response To Other Organism Eosinophil Chemotaxis Eosinophil Migration Mononuclear Cell Migration CCR Chemokine Receptor Binding Response To External Biotic Stimulus CXCR3 Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Cell Migration Regulation Of Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemokine Receptor Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell-cell Signaling Signaling Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Cell Communication	Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Leukocyte Chemotaxis Humoral Immune Response Cytokine Activity Chemokine-mediated Signaling Pathway Leukocyte Migration Myeloid Leukocyte Migration Cell Migration Granulocyte Chemotaxis Cell Motility Killing Of Cells Of Another Organism Granulocyte Migration Inflammatory Response Defense Response To Symbiont Cell Killing Defense Response To Other Organism Immune Response Defense Response Immune System Process Cytokine-mediated Signaling Pathway Response To Other Organism Extracellular Space CXCR Chemokine Receptor Binding CCR Chemokine Receptor Binding Response To External Biotic Stimulus Mononuclear Cell Migration G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Leukocyte Migration Extracellular Region Regulation Of Leukocyte Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Response To Stress Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Eosinophil Chemotaxis Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Eosinophil Migration Regulation Of Cell Motility Positive Regulation Of Monocyte Chemotaxis Regulation Of Locomotion Positive Regulation Of Calcium Ion Transport