XCL1 and CXCL2

Number of citations: 0 (PubMedID 28381538)
Data Source: BioGRID (pull down)

		XCL1	CXCL2
Name		X-C motif chemokine ligand 1	C-X-C motif chemokine ligand 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Killing Of Cells Of Another Organism Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Chemokine receptors bind chemokines G alpha (q) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
GWAS		Blood protein levels ( 30072576 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Metabolite levels ( 23823483 ) Psoriasis ( 34927100 )	Basophil percentage of white cells ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Inflammatory bowel disease ( 23128233 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 29403010 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 29403010 27863252 21738479 ) White blood cell types ( 21738478 )
Novel Interactors		2 novel interactors: FBLN5 TNFSF18	None recorded
Interacting Genes		19 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 KRTAP10-3 PF4 PF4V1 VCAN XCR1	19 interacting genes: CCL11 CCL21 CCL28 CCL5 CCL8 CXCL11 CXCL12 CXCL14 CXCL5 CXCL6 CXCL9 CXCR1 CXCR2 EPS8 PF4 PIK3R1 PLG XCL1 XCL2
Entrez ID		6375	2920
HPRD ID		02595	00741
Ensembl ID		ENSG00000143184	ENSG00000081041
Uniprot IDs		P47992	P19875
PDB IDs		1J8I 1J9O 2HDM 2JP1 2N54 2NYZ 9AST	1QNK 5OB5 8XVU 8XXH
GO Terms Enriched among Interactors		Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine Activity Antimicrobial Humoral Response Chemotaxis Locomotion Leukocyte Chemotaxis Humoral Immune Response Leukocyte Migration Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Migration Granulocyte Migration Cell Motility Killing Of Cells Of Another Organism Extracellular Space Cell Killing Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism CXCR Chemokine Receptor Binding Immune System Process Defense Response Extracellular Region Response To Other Organism Eosinophil Chemotaxis Eosinophil Migration Mononuclear Cell Migration CCR Chemokine Receptor Binding Response To External Biotic Stimulus CXCR3 Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Cell Migration Regulation Of Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemokine Receptor Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell-cell Signaling Signaling Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Cell Communication	Chemokine Activity Leukocyte Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Leukocyte Chemotaxis Chemotaxis Antimicrobial Humoral Response Cell Migration Locomotion Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Motility Granulocyte Migration Cytokine Activity Humoral Immune Response Cytokine-mediated Signaling Pathway Immune System Process Immune Response Mononuclear Cell Migration Defense Response To Symbiont Defense Response To Other Organism Cell Killing Killing Of Cells Of Another Organism Neutrophil Chemotaxis Inflammatory Response CXCR Chemokine Receptor Binding Defense Response Neutrophil Migration Response To Other Organism Response To External Biotic Stimulus G Protein-coupled Receptor Signaling Pathway CCR Chemokine Receptor Binding Chemokine Receptor Binding Extracellular Space Dendritic Cell Migration Extracellular Region Signal Transduction Cell-cell Signaling Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stress Dendritic Cell Chemotaxis Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Motility Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Locomotion Eosinophil Chemotaxis