CEACAM6 and SHC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEACAM6	SHC3
Description		CEA cell adhesion molecule 6	SHC adaptor protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Azurophil Granule Membrane Side Of Membrane	Cytosol Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Phosphotyrosine Residue Binding Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Anoikis	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Intracellular Signal Transduction
Pathways		Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Serum carcinoembryonic antigen levels ( 31666285)	Femur bone mineral density x serum urate levels interaction ( 34046847) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		32 interacting genes: APP ASPG CARTPT CEACAM1 CEACAM5 CEACAM7 CEACAM8 CIB1 CSTF2 EXOC3L1 FOXH1 GCM2 GPANK1 HGS HPCAL4 KANK2 MSS51 MYOZ1 PITX1 POM121 QRICH1 RHOXF2 SHC3 SMARCD1 TLX3 TNXB UBQLN2 VENTX VEZF1 WWOX ZMYND19 ZNF76	58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12
Entrez ID		4680	53358
HPRD ID		01233	12005
Ensembl ID		ENSG00000086548	ENSG00000148082
Uniprot IDs		P40199	Q92529
PDB IDs		4WHC 4WTZ 4Y8A 4YIQ
Enriched GO Terms of Interacting Partners?		Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Central Nervous System Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Developmental Process	Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Structural Constituent Of Skin Epidermis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Tissue Morphogenesis Regulation Of Apoptotic Process Morphogenesis Of An Epithelium Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade ERBB Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Kinase Activity ERBB2 Signaling Pathway Intermediate Filament Cellular Developmental Process Basal Plasma Membrane Positive Regulation Of Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Response To Growth Factor ERBB3:ERBB2 Complex Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Protein Phosphatase Binding Growth Factor Binding Myelination Anatomical Structure Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Axon Ensheathment Neuron Differentiation System Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?