EMC9 and EMC2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		EMC9	EMC2
Description		ER membrane protein complex subunit 9	ER membrane protein complex subunit 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane EMC Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane EMC Complex
	Molecular Function	Protein Binding Membrane Insertase Activity	Protein Binding Membrane Insertase Activity
	Biological Process	Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane	Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Male-pattern baldness ( 27182965 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		2 interacting genes: EMC2 SCN5A	8 interacting genes: CCDC33 EMC8 EMC9 IKZF3 PCDHB12 RHOU SH3BP5L SS18L2
Entrez ID		51016	9694
HPRD ID		16596	09657
Ensembl ID		ENSG00000100908	ENSG00000104412
Uniprot IDs		H0YNH6 Q9Y3B6	Q15006
PDB IDs		6Y4L 6Z3W	6WW7 6Y4L 6Z3W 7ADO 7ADP 8EOI 8J0N 8J0O 8S9S 9C7V
Enriched GO Terms of Interacting Partners?		Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Extrinsic Component Of Endoplasmic Reticulum Membrane Bundle Of His Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential Brainstem Development Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation AV Node Cell To Bundle Of His Cell Communication Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Cardiac Ventricle Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential AV Node Cell Action Potential Positive Regulation Of Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization EMC Complex Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Response To Inactivity Voltage-gated Sodium Channel Complex Nitric-oxide Synthase Binding Membrane Depolarization During Cardiac Muscle Cell Action Potential Cardiac Conduction System Development Membrane Insertase Activity Tail-anchored Membrane Protein Insertion Into ER Membrane Voltage-gated Sodium Channel Activity Ventricular Cardiac Muscle Cell Action Potential Ankyrin Binding Fibroblast Growth Factor Binding Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cell Communication Involved In Cardiac Conduction Membrane Depolarization During Action Potential Telencephalon Development Regulation Of Cardiac Muscle Cell Contraction Protein Insertion Into ER Membrane Positive Regulation Of Sodium Ion Transport Sodium Channel Activity Monoatomic Cation Channel Activity Regulation Of Membrane Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Rate By Cardiac Conduction	Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence EMC Complex Membrane Insertase Activity Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane
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