MSMO1 and CYP4F22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MSMO1	CYP4F22
Description		methylsterol monooxygenase 1	cytochrome P450 family 4 subfamily F member 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	C-4 Methylsterol Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity	Monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process	Lipid Metabolic Process Icosanoid Metabolic Process Ceramide Biosynthetic Process
Pathways		Cholesterol biosynthesis Cholesterol biosynthesis via lathosterol	Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective CYP4F22 causes ARCI5
Drugs		NADH
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Heel bone mineral density ( 30598549) Neuroticism ( 27067015)	Lymphocyte count ( 32888494)
Interacting Genes		19 interacting genes: ATXN1 CHRM5 CYP4F22 DNAJC30 ERG28 GOLT1A GPR35 HMOX1 MARCHF6 MMP14 STRIT1 STX3 TMEM11 TMEM140 TMEM242 TMEM65 TMEM86B VKORC1 YIF1A	4 interacting genes: AQP6 MSMO1 REEP2 TLCD4
Entrez ID		6307	126410
HPRD ID		07396	08256
Ensembl ID		ENSG00000052802	ENSG00000171954
Uniprot IDs		Q15800	Q6NT55
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Taste Receptor Binding Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport C-4 Methylsterol Oxidase Activity Protein Transport Into Membrane Raft Sensory Perception Of Sweet Taste Sensory Perception Of Bitter Taste Monoatomic Anion Channel Activity Ammonium Channel Activity Renal Water Transport Protein Localization To Membrane Raft Ammonium Transmembrane Transport Endoplasmic Reticulum Water Channel Activity Carbon Dioxide Transport Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network One-carbon Compound Transport Water Transport Sensory Perception Of Taste Fluid Transport Cholesterol Biosynthetic Process Channel Activity Sterol Biosynthetic Process Cytoplasmic Microtubule Endoplasmic Reticulum Organization
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