SALL1 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 30385546)
43

Data Source:
BioGRID (pull down)

		SALL1	CRBN
Description		spalt like transcription factor 1	cereblon
Image		No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Chromocenter	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Ventricular Septum Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription By RNA Polymerase II Heart Development Gonad Development Regulation Of Signal Transduction Olfactory Nerve Development Olfactory Bulb Development Olfactory Bulb Interneuron Differentiation Pituitary Gland Development Positive Regulation Of Wnt Signaling Pathway Adrenal Gland Development Inductive Cell-cell Signaling Tube Development Embryonic Digit Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Development Limb Development Olfactory Bulb Mitral Cell Layer Development Kidney Epithelium Development Ureteric Bud Invasion	Protein Ubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Monoatomic Ion Transmembrane Transport Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Limb Development
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Formation of the ureteric bud	Potential therapeutics for SARS
Drugs			Lenalidomide Thalidomide Pomalidomide
Diseases		Townes-Brocks syndrome	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Adventurousness ( 30643258) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Body size at age 10 ( 32376654) C-reactive protein levels ( 21300955 30388399) Cortical thickness ( 32963231) Creatinine levels ( 29403010) Dentures ( 31235808) Diabetes mellitus ( 29615537) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462 30604766) Facial morphology ( 31763980) Femoral neck bone mineral density ( 22504420) Glaucoma (primary open-angle) ( 33627673) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 25631615 31798171 28073927) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Pelvic organ prolapse ( 32184442) Red blood cell count ( 32888494) Serum metabolite levels ( 33031748) Uterine fibroids ( 30194396) Vertical cup-disc ratio ( 25241763 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Weight loss (gastric bypass surgery) ( 23643386) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 27863252 29403010) White matter integrity ( 23218918)
Interacting Genes		10 interacting genes: CRBN CTNNB1 HDAC1 HDAC2 PPP1R13B SUMO1 SUMO2 TERF1 UBE2I USP7	47 interacting genes: APP APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 DNAJA1 EGR1 EGR4 ELF5 GLUL GRB2 GSPT1 GZF1 HDAC6 HIC1 HIC2 HMGB2 HNRNPK HSPA2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS SALL1 SALL3 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 UBE2D3 UBE2G1 WIZ YWHAZ ZBTB16 ZBTB7A ZBTB7B ZFP91 ZMYM2
Entrez ID		6299	51185
HPRD ID		03742	16750
Ensembl ID		ENSG00000103449	ENSG00000113851
Uniprot IDs		Q9NSC2	Q96SW2
PDB IDs			4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV 7LPS 7U8F 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G66 8OIZ 8OJH 8RQ1 8RQ8 8RQ9 8RQA 8RQC 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 9CUO 9DJT 9DJX 9DQD 9FJX 9GAO
Enriched GO Terms of Interacting Partners?		Fungiform Papilla Formation Hair Follicle Placode Formation Protein Modification Process PML Body Presynaptic Cytosol Postsynaptic Cytosol Protein Modification By Small Protein Conjugation Protein Lysine Delactylase Activity Enzyme Binding Transcription Coregulator Binding Regulation Of Oligodendrocyte Differentiation Protein Decrotonylase Activity Histone Decrotonylase Activity Post-translational Protein Modification Protein Sumoylation Small Protein Activating Enzyme Binding Embryonic Digit Morphogenesis Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Odontogenesis Of Dentin-containing Tooth Regulation Of Glial Cell Differentiation P53 Binding Nucleoplasm Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Gliogenesis Protein Metabolic Process Odontogenesis Epidermal Cell Differentiation Protein Lysine Deacetylase Activity Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Telomere Maintenance Protein Tag Activity NuRD Complex Nuclear Body Regulation Of Proteolysis Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Histone Deacetylase Activity Negative Regulation Of Biosynthetic Process SUMO Transferase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transcription Factor Binding Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Macromolecule Metabolic Process Negative Regulation Of Stem Cell Population Maintenance	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Zinc Ion Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Metal Ion Binding Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Nutrient Levels Regulation Of Signaling Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding T Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Lymphocyte Differentiation Mesonephros Development Response To Nutrient Levels
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