SALL1

Name	spalt like transcription factor 1
Structure	No pdb structure
Interactors	10 interactors: CRBN CTNNB1 HDAC1 HDAC2 PPP1R13B SUMO1 SUMO2 TERF1 UBE2I USP7
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Chromocenter
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Ventricular Septum Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription By RNA Polymerase II Heart Development Gonad Development Regulation Of Signal Transduction Olfactory Nerve Development Olfactory Bulb Development Olfactory Bulb Interneuron Differentiation Pituitary Gland Development Positive Regulation Of Wnt Signaling Pathway Adrenal Gland Development Inductive Cell-cell Signaling Tube Development Embryonic Digit Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Development Limb Development Olfactory Bulb Mitral Cell Layer Development Kidney Epithelium Development Ureteric Bud Invasion
Pathways	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Formation of the ureteric bud
Diseases	Townes-Brocks syndrome
GWAS	Adventurousness ( 30643258 ) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325 ) Blood pressure measurement (high sodium and potassium intervention) ( 24165912 ) Body size at age 10 ( 32376654 ) C-reactive protein levels ( 21300955 30388399 ) Cortical thickness ( 32963231 ) Creatinine levels ( 29403010 ) Dentures ( 31235808 ) Diabetes mellitus ( 29615537 ) Digit length ratio ( 29659830 ) Digit length ratio (left hand) ( 29659830 ) Digit length ratio (right hand) ( 29659830 ) Essential hypertension (time to event) ( 32589924 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Facial morphology ( 31763980 ) Femoral neck bone mineral density ( 22504420 ) Glaucoma (primary open-angle) ( 33627673 ) Glomerular filtration rate ( 29403010 ) Heel bone mineral density ( 30598549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 ) Optic cup area ( 25631615 31798171 28073927 ) Optic disc area ( 25631615 31798171 28073927 ) Optic disc parameters ( 20548946 ) Optic disc size ( 31809533 ) Pelvic organ prolapse ( 32184442 ) Red blood cell count ( 32888494 ) Serum metabolite levels ( 33031748 ) Uterine fibroids ( 30194396 ) Vertical cup-disc ratio ( 25241763 31798171 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Weight loss (gastric bypass surgery) ( 23643386 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Entrez ID	6299
HPRD ID	03742
Ensembl ID	ENSG00000103449
Uniprot IDs	Q9NSC2
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Fungiform Papilla Formation Hair Follicle Placode Formation Protein Modification Process PML Body Presynaptic Cytosol Postsynaptic Cytosol Protein Modification By Small Protein Conjugation Protein Lysine Delactylase Activity Enzyme Binding Transcription Coregulator Binding Regulation Of Oligodendrocyte Differentiation Protein Decrotonylase Activity Histone Decrotonylase Activity Post-translational Protein Modification Protein Sumoylation Small Protein Activating Enzyme Binding Embryonic Digit Morphogenesis Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Odontogenesis Of Dentin-containing Tooth Regulation Of Glial Cell Differentiation P53 Binding Nucleoplasm Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Gliogenesis Protein Metabolic Process Odontogenesis Epidermal Cell Differentiation Protein Lysine Deacetylase Activity Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Telomere Maintenance Protein Tag Activity NuRD Complex Nuclear Body Regulation Of Proteolysis Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Histone Deacetylase Activity Negative Regulation Of Biosynthetic Process SUMO Transferase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transcription Factor Binding Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Macromolecule Metabolic Process Negative Regulation Of Stem Cell Population Maintenance