SAFB and RFX2

		SAFB	RFX2
Description		scaffold attachment factor B	regulatory factor X2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Midbody	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding RNA Binding Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Estrogen Receptor Signaling Pathway Regulation Of MRNA Processing Regulation Of Androgen Receptor Signaling Pathway	Acrosome Assembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Spermatid Development Cell Projection Organization Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Heel bone mineral density ( 30598549) Mean platelet volume ( 27863252 32888494) Platelet distribution width ( 32888494)
Interacting Genes		30 interacting genes: ABHD16A CDC37 CEBPA CHD1 CHD3 CLK1 CSNK2A1 CYCS ESR1 HNRNPA1 HNRNPD HNRNPK IL7R LINC00941 MIR199A1 MIR363 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7D NCOR1 POLR2A SAFB2 SREK1 SRPK1 SRPK2 SRSF9 SUMO2 TAF15 TJP2	10 interacting genes: C1orf94 EYA2 FOXJ1 FOXN4 MDFI NFKBID PIAS2 RFX1 RFX4 RFX6
Entrez ID		6294	5990
HPRD ID		04205	00824
Ensembl ID		ENSG00000160633	ENSG00000087903
Uniprot IDs		B7Z2F6 B7ZLP5 Q15424	P48378
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Metabolic Process Regulation Of RNA Splicing MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of MRNA Processing Post-transcriptional Gene Silencing Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RISC Complex Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression RNA Splicing MRNA Base-pairing Post-transcriptional Repressor Activity Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process Chromatin RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Protein Domain Specific Binding Positive Regulation Of Catabolic Process MRNA 3'-UTR Binding Chromatin Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Processing DNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of MRNA Stability Nucleus Nucleic Acid Metabolic Process ATP-dependent Chromatin Remodeler Activity	Regulation Of Nucleobase-containing Compound Metabolic Process Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction DNA Binding Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Androgen Receptor Signaling Pathway Pancreatic Epsilon Cell Differentiation Nucleus
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