RRM1 and ZFPM2

		RRM1	ZFPM2
Description		ribonucleotide reductase catalytic subunit M1	zinc finger protein, FOG family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex Centriolar Satellite Ciliary Basal Body Cell Projection Neuronal Cell Body	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Catalytic Activity Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Oxidoreductase Activity Purine Nucleotide Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	DNA Synthesis Involved In DNA Repair Pyrimidine Nucleobase Metabolic Process Mitochondrial DNA Replication DNA Repair Male Gonad Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye Positive Regulation Of G0 To G1 Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Transcription By RNA Polymerase II Gonadal Mesoderm Development Heart Development Cell Differentiation Lung Development Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development
Pathways		Interconversion of nucleotide di- and triphosphates	Transcriptional regulation of testis differentiation Factors involved in megakaryocyte development and platelet production
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases			Tetralogy of Fallot
GWAS		Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)	Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Basophil count ( 32888494) Birth weight ( 31043758) Brugada syndrome ( 35210625) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778 33020668) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 22570617) HDL cholesterol levels ( 32203549) HOMA-B (corrected for HOMA-IR) ( 30369944) Impulsivity (attentional) ( 30718321) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Platelet count ( 32888494 29403010 33545615 27863252 26805783 22139419) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 27863252 32888494) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976) Takayasu arteritis ( 25604533) Tuberculosis ( 24057671) Vascular endothelial growth factor levels ( 21757650 26910538) Venous thromboembolism ( 31676865 31420334 28373160 25772935) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		11 interacting genes: BMI1 CDC42 CEBPA LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655	13 interacting genes: CTBP1 CTBP2 E2F6 EP300 FMR1 GATA1 GATA3 GATA4 IL32 ITSN1 PRPF3 STAT3 UBQLN4
Entrez ID		6240	23414
HPRD ID		01588	04737
Ensembl ID		ENSG00000167325	ENSG00000169946
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	E7ET52 Q8WW38 Q9NPQ0
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM
Enriched GO Terms of Interacting Partners?		RING-like Zinc Finger Domain Binding Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Regulation Of Store-operated Calcium Entry PRC1 Complex	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Coregulator Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Cell Fate Commitment Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Male Gonad Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Gonad Development Negative Regulation Of Metabolic Process Transcription Coactivator Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Reproductive Structure Development Transcription Repressor Complex Identical Protein Binding Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Developmental Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Chromatin DNA Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T-helper 17 Cell Lineage Commitment Transcription Cis-regulatory Region Binding Cardiac Right Ventricle Morphogenesis Nucleic Acid Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process T-helper Cell Lineage Commitment Chromatin Viral Genome Replication DNA-binding Transcription Factor Activity CD4-positive, Alpha-beta T Cell Lineage Commitment Fat Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex Platelet Formation Alpha-beta T Cell Lineage Commitment Embryonic Hemopoiesis
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