NAV2 and CFAP58

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NAV2	CFAP58
Description		neuron navigator 2	cilia and flagella associated protein 58
Image
GO Annotations	Cellular Component	Interstitial Matrix Nucleus Nucleoplasm Extracellular Matrix	Extracellular Space Cytoplasm Centrosome Cytoskeleton Cilium Motile Cilium Sperm Flagellum Cell Projection Sperm Midpiece
	Molecular Function	Nucleotide Binding Helicase Activity Protein Binding ATP Binding Heparin Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Nervous System Development Sensory Perception Of Sound Sensory Perception Of Smell Locomotory Behavior Optic Nerve Development Glossopharyngeal Nerve Development Vagus Nerve Development Cerebellar Cortex Development Neurogenesis	Notch Signaling Pathway Sperm Axoneme Assembly Cell Projection Organization Flagellated Sperm Motility Cilium Assembly Protein Localization To Motile Cilium Sperm Flagellum Assembly Sperm Mitochondrial Sheath Assembly
Pathways
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Atrial fibrillation ( 29892015 30061737) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117) Brain morphology (MOSTest) ( 32665545) Coronary artery aneurysm in Kawasaki disease ( 27171184) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General cognitive ability ( 29844566) Hepatitis ( 25705159) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lateral thalamic nuclei volume ( 34006833) Low susceptibility to hepatitis C infection ( 31206233) Macular thickness ( 30535121) Monobrow ( 27182965) Obesity-related traits ( 23251661) PR interval ( 32439900 30046033) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Smoking initiation (ever regular vs never regular) ( 30679032) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Waist circumference ( 28552196)
Interacting Genes		12 interacting genes: ADAT2 APC CFAP58 ING4 ING5 MORF4L1 PIAS2 PRPF3 PSTPIP1 RBM15 RBM15B RRAS	7 interacting genes: APP BACH2 FBXL17 KRT27 MCC NAV2 RIPPLY1
Entrez ID		89797	159686
HPRD ID		07385	16583
Ensembl ID		ENSG00000166833	ENSG00000120051
Uniprot IDs		A7E2D6 Q8IVL1	Q5T655
PDB IDs		2YRN	8J07
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Chromatin Disassembly Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Histone H3K4me3 Reader Activity Histone Acetyltransferase Complex Chromatin Organization RNA Modification Nucleoplasm Protein Acetylation Fibroblast Proliferation TRNA Wobble Adenosine To Inosine Editing TRNA-specific Adenosine-34 Deaminase Activity Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process RNA Methylation Regulation Of DNA Biosynthetic Process RNA Metabolic Process	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Primary Adaptive Immune Response Involving T Cells And B Cells Glossopharyngeal Nerve Development Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Vagus Nerve Development Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Axon Midline Choice Point Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Heparin Binding Low-density Lipoprotein Particle Mediated Signaling Primary Adaptive Immune Response Somite Specification Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Locomotory Behavior Axon Choice Point Recognition Interstitial Matrix Cerebellar Cortex Development Heparan Sulfate Binding Signaling Receptor Activator Activity Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Peptidase Activator Activity Cellular Response To Manganese Ion
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