EDEM2

Description		ER degradation enhancing alpha-mannosidase like protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding
	Biological Process	Carbohydrate Metabolic Process Response To Unfolded Protein Glycoprotein Metabolic Process Viral Protein Processing Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Ubiquitin-dependent Glycoprotein ERAD Pathway Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming
Pathways		ER Quality Control Compartment (ERQC) Maturation of spike protein
Drugs
Diseases
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 30275531) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Offspring birth weight ( 31043758) Protein C levels ( 28082259 20802025) Prothrombin time ( 22703881) QRS complex (Cornell) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Venous thromboembolism ( 31676865) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: TRPC4AP
Interacting Genes		1 interacting genes: RPS3A
Entrez ID		55741
HPRD ID		09841
Ensembl ID		ENSG00000088298
Uniprot IDs		Q9BV94
PDB IDs
Enriched GO Terms of Interacting Partners?		Cul4A-RING E3 Ubiquitin Ligase Complex Hair Follicle Maturation Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
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