BCS1L and DNAJA1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		BCS1L	DNAJA1
Description		BCS1 ubiquinol-cytochrome c reductase complex chaperone	DnaJ heat shock protein family (Hsp40) member A1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Hsp70 Protein Binding Tat Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding
	Biological Process	Mitochondrion Organization Protein Insertion Into Mitochondrial Inner Membrane From Matrix Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Cytochrome C Oxidase Assembly Mitochondrial Respiratory Chain Complex III Assembly	Protein Folding Response To Unfolded Protein Response To Heat Negative Regulation Of Protein Ubiquitination Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Mitochondrial protein import Complex III assembly	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases		Bjornstad syndrome Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Male-pattern baldness ( 28196072)
Interacting Genes		3 interacting genes: DDX24 DNAJA1 MTDH	30 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR CRBN DSCR9 ERG FZR1 HIVEP1 HMGCL HSPA8 HUNK LINC01554 LSM2 NELFCD NUDT3 OGT PAXIP1 PGR PTEN PTTG1 SNCA SUMO2 SUMO4 TM4SF1 TXN UBC
Entrez ID		617	3301
HPRD ID		04708	04159
Ensembl ID		ENSG00000074582	ENSG00000086061
Uniprot IDs		A0A024R445 A8JZZ8 Q9Y276	B7Z5C0 P31689
PDB IDs			2LO1 2M6Y 6E8M 8E2O
Enriched GO Terms of Interacting Partners?		Protein Complex Involved In Cell Adhesion	Protein Tag Activity Nucleus Enzyme Binding Negative Regulation Of Protein-containing Complex Assembly Anaphase-promoting Complex Binding Protein Modification By Small Protein Conjugation Ubiquitin Ligase Activator Activity
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