BCS1L and DNAJA1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		BCS1L	DNAJA1
Gene Name		BC1 (ubiquinol-cytochrome c reductase) synthesis-like	DnaJ (Hsp40) homolog, subfamily A, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Respiratory Chain Complex III	Ubiquitin Ligase Complex Nucleus Mitochondrion Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding ATP Binding	G-protein Coupled Receptor Binding Protein Binding ATP Binding Hsp70 Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Mitochondrion Organization Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Respiratory Chain Complex IV Assembly Mitochondrial Respiratory Chain Complex III Assembly	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Protein Refolding DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport
Pathways		Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: DDX24 DNAJA1	20 interactors: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LSM2 NELFCD NUDT3 PAXIP1 PTTG1 SUMO4 TM4SF1 TXN
Entrez ID		617	3301
HPRD ID		04708	04159
Ensembl ID		ENSG00000074582	ENSG00000086061
Uniprot IDs		A8JZZ8 Q9Y276	P31689
PDB IDs			2LO1 2M6Y
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Detection Of DNA Damage Negative Regulation Of JUN Kinase Activity Protein Refolding Negative Regulation Of JNK Cascade Negative Regulation Of Stress-activated MAPK Cascade Toxin Transport Androgen Receptor Signaling Pathway	Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Negative Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination Nucleobase-containing Compound Metabolic Process Protein Polyubiquitination G2 DNA Damage Checkpoint Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Methylation Cell Cycle Checkpoint Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Voltage-gated Chloride Channel Activity Negative Regulation Of Fibril Organization Positive Regulation Of Histone H4-K16 Acetylation Diphosphoinositol Polyphosphate Catabolic Process Negative Regulation Of Potassium Ion Export Diadenosine Polyphosphate Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process DNA Repair Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Heart Rate By Hormone Positive Regulation Of Cellular Protein Metabolic Process See more
Tagcloud ?		adaptations adaptive anaerobic atp branched catabolic catabolism cytoskeleton deficiency dige doors fibroblasts glycolysis glycolytic iii maldi manifestations opening origins oxphos pathophysiological place reprogramming respiration take tof transmitochondrial unambiguously validation	chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Difference) ?		adaptations adaptive anaerobic atp branched catabolic catabolism cytoskeleton deficiency dige doors fibroblasts glycolysis glycolytic iii maldi manifestations opening origins oxphos pathophysiological place reprogramming respiration take tof transmitochondrial unambiguously validation	chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Intersection) ?