RPL37A and IFNGR2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPL37A	IFNGR2
Description		ribosomal protein L37a	interferon gamma receptor 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Ribonucleoprotein Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Zinc Ion Binding Metal Ion Binding	Cytokine Receptor Activity Type II Interferon Receptor Activity Protein Binding
	Biological Process	Cytoplasmic Translation Translation	Microglial Cell Activation Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Defense Response To Virus Type II Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Glutamate Receptor Signaling Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS IFNG signaling activates MAPKs
Drugs			Interferon gamma-1b
Diseases			Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter integrity (fractional anisotropy) ( 32358547)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22936669 23128233 28067908) Diverticular disease ( 30177863) Educational attainment ( 25201988) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 24076602 31604244) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		10 interacting genes: APP BUB3 CTPS2 FBXO7 FOXP1 IFNGR2 LRIF1 MAGEA6 NKX3-1 PRMT1	42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 VMA12 ZDHHC24
Entrez ID		6168	3460
HPRD ID		17997	00956
Ensembl ID		ENSG00000197756	ENSG00000159128
Uniprot IDs		P61513	A8K881 E7EUY1 P38484
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7XNX 7XNY 8A3D 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?		Macrophage Activation Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Myeloid Leukocyte Activation Regulation Of Mitotic Cell Cycle Leukocyte Activation Microglial Cell Activation Cell Activation Leukocyte Activation Involved In Inflammatory Response GATOR1 Complex Binding Response To Testosterone Positive Regulation Of Androgen Secretion MADS Box Domain Binding Bub1-bub3 Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Myeloid Cell Development Negative Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Interleukin-1 Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Chemokine Production Negative Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Negative Regulation Of Macromolecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of Interleukin-1 Beta Production	Membrane Regulation Of Tumor Necrosis Factor Production Type II Interferon-mediated Signaling Pathway Type II Interferon Receptor Binding Oxysterol Binding Macrophage Activation Interferon-mediated Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-23 Production Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Bleb Assembly Cellular Response To Hormone Stimulus Regulation Of Interleukin-23 Production Type III Interferon-mediated Signaling Pathway Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Amyloid-beta Clearance Myeloid Leukocyte Activation Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Virus Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of MHC Class II Biosynthetic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Nitric Oxide Metabolic Process Regulation Of Intracellular Transport Endomembrane System Positive Regulation Of Monocyte Chemotactic Protein-1 Production Neuroinflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Defense Response To Virus Astrocyte Activation Cellular Response To Virus Positive Regulation Of Amyloid-beta Formation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Amyloid-beta Clearance Macrophage Activation Involved In Immune Response Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Steroid Biosynthetic Process Protein Binding
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