RPL13 and ILK

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RPL13	ILK
Description		ribosomal protein L13	integrin linked kinase
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Sarcomere Lamellipodium Cell Projection Anchoring Junction
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Blastocyst Development Cytoplasmic Translation Translation Bone Development	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Mitotic Spindle Organization Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Fibroblast Migration Schwann Cell Development Nerve Development Myelination In Peripheral Nervous System Cell Projection Organization Cell Differentiation Positive Regulation Of BMP Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation Platelet Aggregation Caveola Assembly Protein Localization To Cell Cortex Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Bipolar disorder ( 34002096) Hair morphology traits ( 30166351)	Malaria ( 31844061)
Interacting Genes		24 interacting genes: ANXA7 CEP70 CSNK2A1 CSNK2B DAXX DUX4 ERCC6 ILK IPO5 MAP2K3 MAPKAPK5 OGT PRRC2B PTEN RAD21 RELA RIPK4 SMN1 SPP1 SRPK2 TERF2 TK1 UPF2 WEE2-AS1	43 interacting genes: AKT1 CASP8 CASP9 CAV1 CEBPA CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 OGT PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		6137	3611
HPRD ID		06428	03842
Ensembl ID		ENSG00000167526	ENSG00000166333
Uniprot IDs		A8K4C8 P26373	Q13418 V9HWF0
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Nucleoplasm Negative Regulation Of Cell Cycle Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Response To UV-B Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Protein Kinase Activity Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Protein Serine Kinase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Cytosol Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Protein Localization To Chromosome PML Body Positive Regulation Of Metabolic Process Kinase Activity Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA Repair Regulation Of Protein Metabolic Process Nucleus Positive Regulation Of Biosynthetic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Senescence ATP Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process MAP Kinase Kinase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process	Focal Adhesion Cell-substrate Adhesion Anchoring Junction Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Migration Protein Kinase Binding Positive Regulation Of Cell Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Proteolysis Regulation Of Cellular Localization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Developmental Process Response To Growth Factor Positive Regulation Of Biosynthetic Process Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell-substrate Adhesion ERBB Signaling Pathway Regulation Of Locomotion Integrin Binding Heterotypic Cell-cell Adhesion Negative Regulation Of Developmental Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Actin Binding Regulation Of Actin Filament-based Process Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis T Cell Costimulation Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin
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