RPL12 and IPO11

Number of citations of the paper that reports this interaction (PubMedID 11809816)
42

Data Source:
HPRD (in vivo)

		RPL12	IPO11
Description		ribosomal protein L12	importin 11
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Large Ribosomal Subunit RRNA Binding	Protein Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Cytoplasmic Translation Translation	Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Protein Transport
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS			Alcohol and nicotine co-dependence ( 23216389) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) General risk tolerance (MTAG) ( 30643258) Interstitial lung abnormalities ( 31339356) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma selenium concentration ( 33382417) Subpleural-predominant interstitial lung abnormalities ( 31339356)
Interacting Genes		11 interacting genes: APP CBX1 DUX4 FNDC3B IPO11 OGT OR10G4 PAXIP1 PTEN TTN UBC	14 interacting genes: C1orf94 CEBPA EIF4A2 KEAP1 KRT76 NXF1 PLCD4 RAN RNF10 RPL12 TRAF2 UBE2E1 UBE2E2 UBE2E3
Entrez ID		6136	51194
HPRD ID		01603	10003
Ensembl ID		ENSG00000197958	ENSG00000086200
Uniprot IDs		P30050	Q9UI26
PDB IDs		4V6X 5A8L 5AJ0 6OLG 6ZM7 6ZME 6ZMI 6ZMO 7VB2 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8G5Z 8G60 8G6J 8IDT 8IDY 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8K2C 8RL2 8UKB 8XSX 8XSY 8XSZ 8YOO 8YOP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Cell Junction Assembly Growth Cone Lamellipodium Neuron Projection Organization Enzyme Binding Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Reproductive Behavior Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Vesicle Clustering Membraneless Organelle Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Apoptotic Process Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Chromatin Organization Positive Regulation Of Protein Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Protein O-acetylglucosaminyltransferase Activity Chorion Development Positive Regulation Of RNA Biosynthetic Process	Protein Monoubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity ISG15 Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation ISG15-protein Conjugation Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA-dependent RNA Polymerase Activity Protein Metabolic Process TORC2 Complex Disassembly Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Protein Modification Process TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Protein Autoubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Export From Nucleus Nuclear Pore
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