RPE65 and RBP4

Number of citations of the paper that reports this interaction (PMID 15009723)
6

Data Source:
HPRD (in vitro)

		RPE65	RBP4
Gene Name		retinal pigment epithelium-specific protein 65kDa	retinol binding protein 4, plasma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Organelle Membrane Cell Body	Extracellular Region Extracellular Space Cytosol Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Retinal Isomerase Activity Metal Ion Binding All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity	Protein Binding Retinal Binding Retinol Binding Retinol Transporter Activity Protein Heterodimerization Activity
	Biological Process	Retinoid Metabolic Process Retina Homeostasis Vitamin A Metabolic Process Regulation Of Rhodopsin Gene Expression Visual Perception Phototransduction, Visible Light Insulin Receptor Signaling Pathway Retinol Metabolic Process Retinal Metabolic Process Detection Of Light Stimulus Involved In Visual Perception Retina Morphogenesis In Camera-type Eye Cellular Response To Electrical Stimulus	Retinoid Metabolic Process Eye Development Gluconeogenesis Spermatogenesis Heart Development Phototransduction, Visible Light Male Gonad Development Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Response To Insulin Retinol Transport Retinol Metabolic Process Retinal Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Detection Of Light Stimulus Involved In Visual Perception Positive Regulation Of Immunoglobulin Secretion Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation
Pathways		Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Diseases associated with visual transduction	Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Retinol levels ( 21878437)
Protein-Protein Interactions		2 interactors: RBP4 SLC27A1	5 interactors: ALB GRB2 RBBP6 RPE65 TTR
Entrez ID		6121	5950
HPRD ID		01569	01580
Ensembl ID		ENSG00000116745	ENSG00000138207
Uniprot IDs		Q16518	P02753
PDB IDs			1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ
Enriched GO Terms of Interacting Partners?		Response To Insulin Medium-chain Fatty Acid Transport Lipid Transport Lipid Localization Alcohol Metabolic Process Retinol Transport Female Genitalia Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Response To Peptide Hormone Urinary Bladder Development Response To Peptide Phosphatidylserine Biosynthetic Process Cardiolipin Biosynthetic Process Positive Regulation Of Immunoglobulin Secretion Adiponectin-activated Signaling Pathway Positive Regulation Of Heat Generation Cardiolipin Metabolic Process Phosphatidylglycerol Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Immunoglobulin Secretion Detection Of Light Stimulus Involved In Visual Perception Retinal Metabolic Process Response To Organonitrogen Compound Maintenance Of Gastrointestinal Epithelium Vagina Development Heart Trabecula Formation Uterus Development Genitalia Morphogenesis Response To Hormone Epithelial Structure Maintenance Cellular Lipid Metabolic Process Negative Regulation Of Cardiac Muscle Tissue Development Female Genitalia Development Phosphatidylcholine Biosynthetic Process Phosphatidic Acid Biosynthetic Process Retinol Metabolic Process Phosphatidic Acid Metabolic Process Response To Abiotic Stimulus Heart Trabecula Morphogenesis Phosphatidylserine Metabolic Process Lipid Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Immunoglobulin Production Long-chain Fatty Acid Transport Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cardiac Muscle Cell Proliferation Vitamin Transport Negative Regulation Of Striated Muscle Tissue Development	Retinol Metabolic Process Retina Homeostasis Response To Radiation Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Response To External Stimulus Detection Of Light Stimulus Isoprenoid Metabolic Process Insulin Receptor Signaling Pathway Maintenance Of Mitochondrion Location Detection Of Abiotic Stimulus Hormone Metabolic Process Tissue Homeostasis Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Platelet Activation Cellular Response To Insulin Stimulus Response To Abiotic Stimulus Multicellular Organismal Homeostasis Regulation Of Rhodopsin Gene Expression Thyroid Hormone Transport Regulation Of Hormone Levels Lipid Metabolic Process Response To Insulin Cellular Response To Peptide Hormone Stimulus Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Vitamin A Metabolic Process Cellular Response To Peptide Response To Light Stimulus Alcohol Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Receptor-mediated Endocytosis Sodium-independent Organic Anion Transport Cellular Response To Electrical Stimulus Blood Coagulation Hemostasis Retinal Metabolic Process Detection Of Light Stimulus Involved In Visual Perception Tissue Development Response To Peptide Hormone Establishment Of Epithelial Cell Polarity Regulation Of Circadian Sleep/wake Cycle, Sleep Cellular Response To Organonitrogen Compound Embryonic Organ Development Response To Peptide Positive Regulation Of Circadian Rhythm
Tagcloud ?		acyltransferase amaurosis blindness combinatorial cone culprit cyclase degeneration disrupt emphasizes galphat2 gc1 grk1 guanylate hereditary lca leber lecithin lrat mistrafficking opn1sw opsin opsins photoreceptor photoreceptors retinal retinol transducin vision	acyltransferase cas9 conjunction crispr drives editing encodes es h3k27 kat3b kidneys lecithin lrat marks promoters ra rargamma retinol rxralpha stra6 stra6l stra6s suz12 transcribed transcript trimethylation usage vad vitamin
Tagcloud (Difference) ?		amaurosis blindness combinatorial cone culprit cyclase degeneration disrupt emphasizes galphat2 gc1 grk1 guanylate hereditary lca leber mistrafficking opn1sw opsin opsins photoreceptor photoreceptors retinal transducin vision	cas9 conjunction crispr drives editing encodes es h3k27 kat3b kidneys marks promoters ra rargamma rxralpha stra6 stra6l stra6s suz12 transcribed transcript trimethylation usage vad vitamin
Tagcloud (Intersection) ?		acyltransferase lecithin lrat retinol