RPE65 and SLC27A1

Number of citations of the paper that reports this interaction (PMID 20356843)
3

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RPE65	SLC27A1
Gene Name		retinal pigment epithelium-specific protein 65kDa	solute carrier family 27 (fatty acid transporter), member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Organelle Membrane Cell Body	Endoplasmic Reticulum Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Retinal Isomerase Activity Metal Ion Binding All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Fatty Acid Transporter Activity Very Long-chain Fatty Acid-CoA Ligase Activity Protein Homodimerization Activity
	Biological Process	Retinoid Metabolic Process Retina Homeostasis Vitamin A Metabolic Process Regulation Of Rhodopsin Gene Expression Visual Perception Phototransduction, Visible Light Insulin Receptor Signaling Pathway Retinol Metabolic Process Retinal Metabolic Process Detection Of Light Stimulus Involved In Visual Perception Retina Morphogenesis In Camera-type Eye Cellular Response To Electrical Stimulus	Medium-chain Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Phosphatidylcholine Biosynthetic Process Phosphatidylserine Biosynthetic Process Phosphatidylinositol Biosynthetic Process Response To Cold Long-chain Fatty Acid Transport Positive Regulation Of Heat Generation Cardiolipin Biosynthetic Process Response To Insulin Adiponectin-activated Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Transmembrane Transport Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Diseases associated with visual transduction	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transport of vitamins, nucleosides, and related molecules SLC-mediated transmembrane transport Transport of fatty acids
Drugs
Diseases
GWAS			Response to antidepressants ( 20360315)
Protein-Protein Interactions		2 interactors: RBP4 SLC27A1	1 interactors: RPE65
Entrez ID		6121	376497
HPRD ID		01569	11863
Ensembl ID		ENSG00000116745	ENSG00000130304
Uniprot IDs		Q16518	Q6PCB7
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Insulin Medium-chain Fatty Acid Transport Lipid Transport Lipid Localization Alcohol Metabolic Process Retinol Transport Female Genitalia Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Response To Peptide Hormone Urinary Bladder Development Response To Peptide Phosphatidylserine Biosynthetic Process Cardiolipin Biosynthetic Process Positive Regulation Of Immunoglobulin Secretion Adiponectin-activated Signaling Pathway Positive Regulation Of Heat Generation Cardiolipin Metabolic Process Phosphatidylglycerol Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Immunoglobulin Secretion Detection Of Light Stimulus Involved In Visual Perception Retinal Metabolic Process Response To Organonitrogen Compound Maintenance Of Gastrointestinal Epithelium Vagina Development Heart Trabecula Formation Uterus Development Genitalia Morphogenesis Response To Hormone Epithelial Structure Maintenance Cellular Lipid Metabolic Process Negative Regulation Of Cardiac Muscle Tissue Development Female Genitalia Development Phosphatidylcholine Biosynthetic Process Phosphatidic Acid Biosynthetic Process Retinol Metabolic Process Phosphatidic Acid Metabolic Process Response To Abiotic Stimulus Heart Trabecula Morphogenesis Phosphatidylserine Metabolic Process Lipid Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Immunoglobulin Production Long-chain Fatty Acid Transport Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cardiac Muscle Cell Proliferation Vitamin Transport Negative Regulation Of Striated Muscle Tissue Development	Regulation Of Rhodopsin Gene Expression Vitamin A Metabolic Process Cellular Response To Electrical Stimulus Detection Of Light Stimulus Involved In Visual Perception Retinal Metabolic Process Retinol Metabolic Process Response To Electrical Stimulus Photoreceptor Cell Development Retina Morphogenesis In Camera-type Eye Retina Homeostasis Phototransduction, Visible Light Cellular Aldehyde Metabolic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Vitamin Metabolic Process Isoprenoid Metabolic Process Camera-type Eye Morphogenesis Insulin Receptor Signaling Pathway Eye Morphogenesis Retina Development In Camera-type Eye Visual Perception Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Hormone Metabolic Process Tissue Homeostasis Cellular Response To Insulin Stimulus Multicellular Organismal Homeostasis Regulation Of Hormone Levels Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Light Stimulus Alcohol Metabolic Process Camera-type Eye Development Eye Development Detection Of Stimulus Involved In Sensory Perception Response To Radiation Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Detection Of Stimulus Cellular Response To Hormone Stimulus Sensory Organ Development Tissue Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tagcloud ?		acyltransferase amaurosis blindness combinatorial cone culprit cyclase degeneration disrupt emphasizes galphat2 gc1 grk1 guanylate hereditary lca leber lecithin lrat mistrafficking opn1sw opsin opsins photoreceptor photoreceptors retinal retinol transducin vision	1n9 angus asb3 backfat corticotropin crossbreeding dermatan desaturase dsel efemp1 epimerase fibulin gng3 hardy healthful heterosis linolenic marbling oleic overdominant palmitic parentage pltp sires solute wagyu wagyuxangus weinberg
Tagcloud (Difference) ?		acyltransferase amaurosis blindness combinatorial cone culprit cyclase degeneration disrupt emphasizes galphat2 gc1 grk1 guanylate hereditary lca leber lecithin lrat mistrafficking opn1sw opsin opsins photoreceptor photoreceptors retinal retinol transducin vision	1n9 angus asb3 backfat corticotropin crossbreeding dermatan desaturase dsel efemp1 epimerase fibulin gng3 hardy healthful heterosis linolenic marbling oleic overdominant palmitic parentage pltp sires solute wagyu wagyuxangus weinberg
Tagcloud (Intersection) ?