RPE65

Description		retinoid isomerohydrolase RPE65
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cell Body
	Molecular Function	Phosphatidylserine Binding Beta-carotene 15,15'-dioxygenase Activity Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Isomerase Activity Phosphatidylcholine Binding Metal Ion Binding Retinol Isomerase Activity All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Cardiolipin Binding
	Biological Process	Retinoid Metabolic Process Retina Homeostasis Neural Retina Development Lipid Metabolic Process Vitamin A Metabolic Process Visual Perception Circadian Rhythm Response To Light Stimulus Retinol Metabolic Process Retinal Metabolic Process Camera-type Eye Development Detection Of Light Stimulus Involved In Visual Perception Zeaxanthin Biosynthetic Process
Pathways		The canonical retinoid cycle in rods (twilight vision)
Drugs		Voretigene neparvovec
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Facial morphology ( 31763980) Glaucoma (primary open-angle) ( 33627673) HDL cholesterol levels in HIV infection ( 33109212) Mortality in sepsis ( 27639821) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		2 interacting genes: RBP4 SLC27A1
Entrez ID		6121
HPRD ID		01569
Ensembl ID		ENSG00000116745
Uniprot IDs		Q16518
PDB IDs
Enriched GO Terms of Interacting Partners?		Lipid Import Into Cell Vitamin Transmembrane Transport Vitamin Transport Response To Insulin Retinol Transmembrane Transporter Activity Female Genitalia Morphogenesis Lipid Transport Vitamin A Import Into Cell Response To Peptide Hormone Terpenoid Transport Retinol Transport Urinary Bladder Development Biotin Import Across Plasma Membrane Biotin Transport Medium-chain Fatty Acid Transport Biotin Transmembrane Transporter Activity Long-chain Fatty Acid Import Across Plasma Membrane Oleoyl-CoA Ligase Activity Lipid Transport Across Blood-brain Barrier Glucose Import In Response To Insulin Stimulus Embryonic Retina Morphogenesis In Camera-type Eye Fatty Acid Transmembrane Transporter Activity Molecular Carrier Activity Retinoid Binding Import Into Cell Retinal Binding Response To Hormone Vagina Development Very Long-chain Fatty Acid-CoA Ligase Activity Efflux Transmembrane Transporter Activity Positive Regulation Of Heat Generation Arachidonate-CoA Ligase Activity Long-chain Fatty Acid Import Into Cell Adiponectin-activated Signaling Pathway Genitalia Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Heart Trabecula Formation Retinol Binding Phototransduction, Visible Light Positive Regulation Of Triglyceride Biosynthetic Process Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transmembrane Transporter Activity Female Genitalia Development Retinal Metabolic Process D-glucose Import Regulation Of Triglyceride Biosynthetic Process Detection Of Light Stimulus Involved In Visual Perception Uterus Development Positive Regulation Of Triglyceride Metabolic Process Detection Of Visible Light
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