PNRC2

Description		proline rich nuclear receptor coactivator 2
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		23 interacting genes: APP AR BANP DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GALK1 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48
Entrez ID		55629
HPRD ID		17871
Ensembl ID		ENSG00000189266
Uniprot IDs		Q9NPJ4
PDB IDs		4B6H 5KQ1 5KQ4
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of RNA Metabolic Process Estrogen Response Element Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Steroid Receptor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Zinc Ion Binding Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Developmental Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Transcription Coactivator Binding Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Estrogen Stimulus Regulation Of Cell Differentiation Cellular Response To Lipid
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