PNRC2 and RARG

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PNRC2	RARG
Gene Name		proline-rich nuclear receptor coactivator 2	retinoic acid receptor, gamma
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Integral Component Of Membrane
	Molecular Function	Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Retinoid X Receptor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Transcription, DNA-templated Regulation Of Transcription, DNA-templated Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Glandular Epithelial Cell Development Retinal Pigment Epithelium Development Growth Plate Cartilage Chondrocyte Growth Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Size Anterior/posterior Pattern Specification Gene Expression Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Transmembrane Transport Canonical Wnt Signaling Pathway Face Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid
Pathways			Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate SR11254 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: AR DCP1A ESR1 ESR2 ESRRA ESRRG GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SF1 SPAG9 XRCC6 ZBTB16 ZBTB48	29 interactors: ACY3 EIF3I HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 RHPN2 RXRA RXRB RXRG SMAD3 SPHK1 SRC SRF TNIP1 ZNF576
Entrez ID		55629	5916
HPRD ID		17871	01573
Ensembl ID		ENSG00000189266	ENSG00000172819
Uniprot IDs		Q9NPJ4	A8K3H3 B7Z4B4 F1D8P1 P13631
PDB IDs		4B6H	1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Organic Substance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Organ Development Response To Organic Substance Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process System Development Developmental Process Involved In Reproduction Prostate Gland Development Sex Differentiation Multicellular Organismal Development Anatomical Structure Development Regulation Of Metabolic Process	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription, DNA-templated Response To Steroid Hormone Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process DNA-templated Transcription, Initiation Response To Hormone Gene Expression Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Response To Lipid Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Steroid Hormone Mediated Signaling Pathway Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Cellular Response To Hormone Stimulus Cellular Response To Lipid Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gland Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Organ Development System Development Intracellular Steroid Hormone Receptor Signaling Pathway In Utero Embryonic Development Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Nucleobase-containing Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		2d af alternatives biologically circular coactivators cognate competitive confirms constitutes coregulator coregulators dichroism ecd eralpha eralpha17p exception exhaustive governing grb2 issued motifs polyproline ppii pxxp sh3 spectroscopy transductions	activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants
Tagcloud (Difference) ?		2d af alternatives biologically circular coactivators cognate competitive confirms constitutes coregulator coregulators dichroism ecd eralpha eralpha17p exception exhaustive governing grb2 issued motifs polyproline ppii pxxp sh3 spectroscopy transductions	activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants
Tagcloud (Intersection) ?