PNRC2 and NR5A2

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PNRC2	NR5A2
Gene Name		proline-rich nuclear receptor coactivator 2	nuclear receptor subfamily 5, group A, member 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Transcription, DNA-templated Regulation Of Transcription, DNA-templated Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Bile Acid Metabolic Process Embryo Development Gene Expression Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Regulation Of Cell Proliferation Homeostatic Process Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Viral Genome Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Pancreatic cancer ( 20101243)
Protein-Protein Interactions		20 interactors: AR DCP1A ESR1 ESR2 ESRRA ESRRG GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SF1 SPAG9 XRCC6 ZBTB16 ZBTB48	19 interactors: ALB BCKDK COPS5 EDF1 FTH1 NCOA1 NCOA3 NPPA NR0B2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 SMARCD3 SRC UBE2I
Entrez ID		55629	2494
HPRD ID		17871	06830
Ensembl ID		ENSG00000189266	ENSG00000116833
Uniprot IDs		Q9NPJ4	B4E2P3 F1D8R9 O00482
PDB IDs		4B6H	1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Organic Substance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Organ Development Response To Organic Substance Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process System Development Developmental Process Involved In Reproduction Prostate Gland Development Sex Differentiation Multicellular Organismal Development Anatomical Structure Development Regulation Of Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Metabolic Process Cellular Metabolic Process Metabolic Process Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Labyrinthine Layer Morphogenesis Positive Regulation Of Organelle Assembly Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Placenta Morphogenesis Gland Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Response To Nutrient Levels Mammary Gland Development Anatomical Structure Development Negative Regulation Of Gene Expression Response To Extracellular Stimulus Negative Regulation Of Biosynthetic Process
Tagcloud ?		2d af alternatives biologically circular coactivators cognate competitive confirms constitutes coregulator coregulators dichroism ecd eralpha eralpha17p exception exhaustive governing grb2 issued motifs polyproline ppii pxxp sh3 spectroscopy transductions	4f 6f boosts copyright dn endogenously epiblast episcs feeder impedes ipscs klf4 lrh1 mef mefs n2b27 oct4 pluripotency pluripotent primed rarg reprogram reprogramming reprograms reserved rights sox2 supplementing synthesised
Tagcloud (Difference) ?		2d af alternatives biologically circular coactivators cognate competitive confirms constitutes coregulator coregulators dichroism ecd eralpha eralpha17p exception exhaustive governing grb2 issued motifs polyproline ppii pxxp sh3 spectroscopy transductions	4f 6f boosts copyright dn endogenously epiblast episcs feeder impedes ipscs klf4 lrh1 mef mefs n2b27 oct4 pluripotency pluripotent primed rarg reprogram reprogramming reprograms reserved rights sox2 supplementing synthesised
Tagcloud (Intersection) ?