RNASE2 and ABCE1

Number of citations of the paper that reports this interaction (PubMedID 12578357)
0

Data Source:
HPRD (in vitro, in vivo)

		RNASE2	ABCE1
Description		ribonuclease A family member 2	ATP binding cassette subfamily E member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Azurophil Granule Lumen Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Cytosolic Ribosome
	Molecular Function	Lipopolysaccharide Binding Nucleic Acid Binding Nuclease Activity Endonuclease Activity Ribonuclease A Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Lyase Activity	Nucleotide Binding GTPase Activity Iron Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Ribosomal Small Subunit Binding CTPase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Endoribonuclease Inhibitor Activity
	Biological Process	Innate Immune Response In Mucosa RNA Catabolic Process Chemotaxis Induction Of Bacterial Agglutination Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Virus	Translation Translational Initiation Translational Termination Regulation Of Translation Ribosome Disassembly Regulation Of Macromolecule Metabolic Process Negative Regulation Of Endoribonuclease Activity Protein Ufmylation Rescue Of Stalled Ribosome CAT Tailing Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Neutrophil degranulation	OAS antiviral response Interferon alpha/beta signaling PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
Drugs		Adenosine 3',5'-diphosphate Adenosine-2'-5'-Diphosphate
Diseases
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 20570966)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: ABCE1 DLG2 GEMIN4 YWHAQ	4 interacting genes: CEBPA EIF3J RNASE2 RNASEL
Entrez ID		6036	6059
HPRD ID		00577	03132
Ensembl ID		ENSG00000169385	ENSG00000164163
Uniprot IDs		P10153 W0UV60	P61221
PDB IDs		1GQV 1HI2 1HI3 1HI4 1HI5 1K2A 2BEX 2BZZ 2C01 2C02 2C05 5E13 6SSO 8F5X 8QEW	6ZME 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?		Retrograde Axonal Protein Transport Endoribonuclease Inhibitor Activity Regulation Of Endoribonuclease Activity Negative Regulation Of Endoribonuclease Activity Negative Regulation Of Nuclease Activity Regulation Of Ribonuclease Activity Cytoplasmic Translational Elongation CTPase Activity CAT Tailing Juxtaparanode Region Of Axon GMP Kinase Activity GDP Metabolic Process Protein Transport Along Microtubule Anterograde Axonal Protein Transport Ribonucleoside Triphosphate Phosphatase Activity Translational Termination Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Protein Ufmylation SMN Complex Gemini Of Cajal Bodies Cellular Response To Potassium Ion Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Response To Potassium Ion Retrograde Axonal Transport Ribosomal Small Subunit Binding	RNA Nuclease Activity Fat Cell Differentiation Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Nuclease Activity Ribonuclease A Activity Endonuclease Activity CHOP-C/EBP Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Induction Of Bacterial Agglutination Response To Phenylpropanoid Defense Response To Virus Defense Response Fat Cell Proliferation RNA Metabolic Process Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway Identical Protein Binding STAT Family Protein Binding Osteoblast Development Response To Virus Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Innate Immune Response In Mucosa
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