RNASE2 and GEMIN4

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		RNASE2	GEMIN4
Description		ribonuclease A family member 2	gem nuclear organelle associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Azurophil Granule Lumen Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies
	Molecular Function	Lipopolysaccharide Binding Nucleic Acid Binding Nuclease Activity Endonuclease Activity Ribonuclease A Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Lyase Activity	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Innate Immune Response In Mucosa RNA Catabolic Process Chemotaxis Induction Of Bacterial Agglutination Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Virus	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing
Pathways		Neutrophil degranulation	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs		Adenosine 3',5'-diphosphate Adenosine-2'-5'-Diphosphate
Diseases
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 20570966)	Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: ABCE1 DLG2 GEMIN4 YWHAQ	57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35
Entrez ID		6036	50628
HPRD ID		00577	07370
Ensembl ID		ENSG00000169385	ENSG00000179409
Uniprot IDs		P10153 W0UV60	I3L2C7 P57678 Q8WUM5 Q9HC39
PDB IDs		1GQV 1HI2 1HI3 1HI4 1HI5 1K2A 2BEX 2BZZ 2C01 2C02 2C05 5E13 6SSO 8F5X 8QEW
Enriched GO Terms of Interacting Partners?		Retrograde Axonal Protein Transport Endoribonuclease Inhibitor Activity Regulation Of Endoribonuclease Activity Negative Regulation Of Endoribonuclease Activity Negative Regulation Of Nuclease Activity Regulation Of Ribonuclease Activity Cytoplasmic Translational Elongation CTPase Activity CAT Tailing Juxtaparanode Region Of Axon GMP Kinase Activity GDP Metabolic Process Protein Transport Along Microtubule Anterograde Axonal Protein Transport Ribonucleoside Triphosphate Phosphatase Activity Translational Termination Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Protein Ufmylation SMN Complex Gemini Of Cajal Bodies Cellular Response To Potassium Ion Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Response To Potassium Ion Retrograde Axonal Transport Ribosomal Small Subunit Binding	SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?