WDR74 and RGS2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		WDR74	RGS2
Description		WD repeat domain 74	regulator of G protein signaling 2
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Preribosome, Large Subunit Precursor	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Adenylate Cyclase Inhibitor Activity Beta-tubulin Binding
	Biological Process	Blastocyst Formation RRNA Processing RNA Metabolic Process Ribosomal Large Subunit Biogenesis	Response To Amphetamine Regulation Of Translation G Protein-coupled Receptor Signaling Pathway Spermatogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of JNK Cascade Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways			G alpha (q) signalling events
Drugs
Diseases
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		5 interacting genes: CEBPA DLG4 NUDT3 RCHY1 RGS2	61 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		54663	5997
HPRD ID		08548	02917
Ensembl ID		ENSG00000133316	ENSG00000116741
Uniprot IDs		Q6RFH5	P41220
PDB IDs		8FKP 8FKR 8FKT 8FKV	2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?		Brown Fat Cell Differentiation Kinase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process P2Y1 Nucleotide Receptor Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity White Fat Cell Proliferation Adenylate Cyclase Inhibitor Activity Bis(5'-adenosyl)-pentaphosphatase Activity Diadenosine Polyphosphate Catabolic Process Cellular Response To Metal Ion Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding Error-free Translesion Synthesis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process NMDA Selective Glutamate Receptor Signaling Pathway Relaxation Of Vascular Associated Smooth Muscle Developmental Maturation Positive Regulation Of Protein Catabolic Process Response To Phenylpropanoid D1 Dopamine Receptor Binding	Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Guanyl Nucleotide Binding Calyx Of Held G-protein Beta/gamma-subunit Complex Binding Cognition Nucleotide Binding Regulation Of Secretion By Cell Scaffold Protein Binding Protein-containing Complex Binding Learning Or Memory Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Regulation Of Transport Response To Ketone Regulation Of Secretion Enzyme Binding Histone H3T6 Kinase Activity Regulation Of Neurotransmitter Secretion Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Corticosterone Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Regulation Of Insulin Secretion Regulation Of Muscle System Process Regulation Of Muscle Contraction Response To Alcohol Regulation Of Protein Secretion System Process Response To Catecholamine Cytoplasm Nervous System Process Adrenergic Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Exocytosis Response To Hormone Cellular Localization Protein Kinase C Signaling Membrane Regulation Of Peptide Hormone Secretion Establishment Of Localization In Cell Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization G Protein-coupled Receptor Signaling Pathway Centrosome Regulation Of Establishment Of Protein Localization Response To Psychosocial Stress Adenylate Cyclase Activator Activity Intracellular Protein Localization G Protein Activity
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