RFX4 and RFX3

Number of citations: 0 (PubMedID 11682486)
Data Source: HPRD (in vitro, in vivo)

		RFX4	RFX3
Name		regulatory factor X4	regulatory factor X3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Extracellular Region Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Telencephalon Development Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Regulation Of Protein Processing	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Cell Differentiation Endocrine Pancreas Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of Insulin Secretion Cilium Assembly Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development
GWAS		A body shape index ( 34021172 ) Brain morphology (MOSTest) ( 32665545 ) Chronotype ( 30696823 ) Cognitive test performance ( 17903297 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heart rate ( 23583979 ) Morning person ( 30696823 ) Night sleep phenotypes ( 27126917 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Triglyceride levels ( 28334899 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Bisphosphonate-associated atypical femoral fracture ( 31006051 ) Body mass index ( 28552196 ) Gout ( 25967671 ) Insomnia ( 29520036 ) Major depressive disorder ( 27479909 ) Monobrow thickness ( 26926045 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure in sickle cell anemia ( 24058526 ) Weight ( 28552196 )
Novel Interactors		None recorded	6 novel interactors: AK3 CDK1 NANS PBRM1 SLC1A3 TMEM9B
Interacting Genes		3 interacting genes: ESR1 RFX2 RFX3	13 interacting genes: BIN1 CREB1 EWSR1 FHL2 FHL3 IRF6 MEOX2 PKNOX1 RFX1 RFX4 RFX6 TRAF2 TRIP6
Entrez ID		5992	5991
HPRD ID		04905	03215
Ensembl ID		ENSG00000111783	ENSG00000080298
Uniprot IDs		Q33E94	P48380
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transcription Regulator Complex Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cilium Assembly Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Cilium Organization Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of RNA Metabolic Process Plasma Membrane Bounded Cell Projection Assembly Nitric-oxide Synthase Regulator Activity Cell Projection Assembly Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Prostate Gland Growth Vagina Development Estrogen Response Element Binding Sequence-specific DNA Binding Branching Involved In Prostate Gland Morphogenesis Branch Elongation Of An Epithelium Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Regulation Of Hormone Levels Mammary Gland Epithelial Cell Proliferation Cell Differentiation Regulation Of Transcription By RNA Polymerase II Female Genitalia Development Cellular Component Assembly Endocrine Pancreas Development Branching Involved In Mammary Gland Duct Morphogenesis Axis Elongation	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Ventricular Cardiac Muscle Cell Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Nucleobase-containing Compound Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Z Disc Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Pronuclear Fusion Epithelial Cell Differentiation Cardiac Muscle Cell Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cardiac Cell Development DNA Binding Response To Cocaine Chemotaxis To Arachidonate TORC2 Complex Disassembly N-acetylneuraminate Synthase Activity N-acylneuraminate-9-phosphate Synthase Activity Pancreatic Epsilon Cell Differentiation Regulation Of Macromolecule Metabolic Process Hsp70 Protein Binding Nucleus Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Cardiac Muscle Tissue Development Sequence-specific DNA Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of Transcription By RNA Polymerase II Atrial Cardiac Muscle Cell Development Limb Development TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Nucleoside Triphosphate Adenylate Kinase Activity