RFX4 and RFX2

Number of citations: 0 (PubMedID 11682486)
Data Source: HPRD (in vitro, in vivo, two hybrid)

		RFX4	RFX2
Name		regulatory factor X4	regulatory factor X2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Telencephalon Development Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Regulation Of Protein Processing	Acrosome Assembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Spermatid Development Cell Projection Organization Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Cellular Response To Leukemia Inhibitory Factor
GWAS		A body shape index ( 34021172 ) Brain morphology (MOSTest) ( 32665545 ) Chronotype ( 30696823 ) Cognitive test performance ( 17903297 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heart rate ( 23583979 ) Morning person ( 30696823 ) Night sleep phenotypes ( 27126917 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Triglyceride levels ( 28334899 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Heel bone mineral density ( 30598549 ) Mean platelet volume ( 27863252 32888494 ) Platelet distribution width ( 32888494 )
Novel Interactors		None recorded	7 novel interactors: HNRNPM ICAM3 MYO1F SAFB SNAPC2 STXBP2 ZNF14
Interacting Genes		3 interacting genes: ESR1 RFX2 RFX3	10 interacting genes: C1orf94 EYA2 FOXJ1 FOXN4 MDFI NFKBID PIAS2 RFX1 RFX4 RFX6
Entrez ID		5992	5990
HPRD ID		04905	00824
Ensembl ID		ENSG00000111783	ENSG00000087903
Uniprot IDs		Q33E94	P48378
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transcription Regulator Complex Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cilium Assembly Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Cilium Organization Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of RNA Metabolic Process Plasma Membrane Bounded Cell Projection Assembly Nitric-oxide Synthase Regulator Activity Cell Projection Assembly Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Prostate Gland Growth Vagina Development Estrogen Response Element Binding Sequence-specific DNA Binding Branching Involved In Prostate Gland Morphogenesis Branch Elongation Of An Epithelium Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Regulation Of Hormone Levels Mammary Gland Epithelial Cell Proliferation Cell Differentiation Regulation Of Transcription By RNA Polymerase II Female Genitalia Development Cellular Component Assembly Endocrine Pancreas Development Branching Involved In Mammary Gland Duct Morphogenesis Axis Elongation	Regulation Of Nucleobase-containing Compound Metabolic Process Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction DNA Binding Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Androgen Receptor Signaling Pathway Pancreatic Epsilon Cell Differentiation Nucleus