RFX3 and PBRM1

		RFX3	PBRM1
Description		regulatory factor X3	polybromo 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Transcription Regulator Complex	Nuclear Chromosome Kinetochore Chromatin Nucleus Nucleoplasm Chromosome Nuclear Matrix SWI/SNF Complex RSC-type Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Binding
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Cell Differentiation Endocrine Pancreas Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of Insulin Secretion Cilium Assembly Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways			RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Formation of the polybromo-BAF (pBAF) complex
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Body mass index ( 28552196) Gout ( 25967671) Insomnia ( 29520036) Major depressive disorder ( 27479909) Monobrow thickness ( 26926045) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure in sickle cell anemia ( 24058526) Weight ( 28552196)	A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Hemoglobin levels ( 32327693) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Intelligence (MTAG) ( 29326435) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Major mood disorders ( 20081856) Red cell distribution width ( 32888494) Schizophrenia ( 30285260 28991256 23974872 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		13 interacting genes: BIN1 CREB1 EWSR1 FHL2 FHL3 IRF6 MEOX2 PKNOX1 RFX1 RFX4 RFX6 TRAF2 TRIP6	13 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 PTEN PTS SMARCA4 SUMO2 UBE3A USP7 ZDHHC17 ZNF512B
Entrez ID		5991	55193
HPRD ID		03215	07302
Ensembl ID		ENSG00000080298	ENSG00000163939
Uniprot IDs		P48380	A0A9L9PXL4 Q86U86
PDB IDs			2KTB 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID 6OXB 6ZN6 6ZNV 6ZS3 6ZS4 7VDV 7Y8R 8FTA
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Ventricular Cardiac Muscle Cell Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Nucleobase-containing Compound Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Z Disc Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Pronuclear Fusion Epithelial Cell Differentiation Cardiac Muscle Cell Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cardiac Cell Development DNA Binding Response To Cocaine Chemotaxis To Arachidonate TORC2 Complex Disassembly N-acetylneuraminate Synthase Activity N-acylneuraminate-9-phosphate Synthase Activity Pancreatic Epsilon Cell Differentiation Regulation Of Macromolecule Metabolic Process Hsp70 Protein Binding Nucleus Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Cardiac Muscle Tissue Development Sequence-specific DNA Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of Transcription By RNA Polymerase II Atrial Cardiac Muscle Cell Development Limb Development TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Nucleoside Triphosphate Adenylate Kinase Activity	Regulation Of Ubiquitin-dependent Protein Catabolic Process Structural Constituent Of Chromatin Regulation Of Proteolysis Chromatin Remodeling Nucleosome Epigenetic Regulation Of Gene Expression Nucleosome Organization Axonogenesis Protein Heterodimerization Activity Chromatin Organization Protein-DNA Complex Assembly Regulation Of MiRNA Transcription Positive Regulation Of Proteolysis Regulation Of MiRNA Metabolic Process System Development Neuron Projection Morphogenesis PML Body Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleosome Assembly Cell Projection Morphogenesis Negative Regulation Of MiRNA Transcription Postsynaptic Cytosol Positive Regulation Of Catabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Hormone Biosynthetic Process Negative Regulation Of Synaptic Vesicle Clustering 6-pyruvoyltetrahydropterin Synthase Activity Sperm Entry Positive Regulation Of Golgi Lumen Acidification Xylosylprotein 4-beta-galactosyltransferase Activity Perforant Pathway To Dendrate Granule Cell Synapse DNA Binding Neuron Projection Organization Regulation Of Protein Catabolic Process Negative Regulation Of Gene Expression, Epigenetic
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