RFX4

Gene Name		regulatory factor X, 4 (influences HLA class II expression)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Dorsal Spinal Cord Development Telencephalon Development Cerebellar Cortex Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Midbrain Development Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Processing
Pathways
Drugs
Diseases
GWAS		Cognitive test performance ( 17903297) Heart rate ( 23583979)
Protein-protein Interactions		3 interactors: ESR1 RFX2 RFX3
Entrez ID		5992
HPRD ID		04905
Ensembl ID		ENSG00000111783
Uniprot IDs		Q33E94
PDB IDs
Enriched GO Terms of Interacting Partners?		Epithelial Cell Development Type B Pancreatic Cell Maturation Prostate Epithelial Cord Elongation Cilium-dependent Cell Motility Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Glandular Epithelial Cell Maturation Transcription, DNA-templated Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy RNA Biosynthetic Process Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Or Flagellum-dependent Cell Motility Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Epithelial Cell Differentiation Regulation Of Type B Pancreatic Cell Development Vagina Development Uterus Development Type B Pancreatic Cell Development Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Prostate Gland Growth Cellular Response To Estradiol Stimulus Epithelial Cell Maturation Branching Involved In Prostate Gland Morphogenesis RNA Metabolic Process Mammary Gland Epithelial Cell Proliferation Epithelial Cilium Movement Type B Pancreatic Cell Differentiation Female Genitalia Development Enteroendocrine Cell Differentiation Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium Gene Expression Cellular Response To Estrogen Stimulus Glandular Epithelial Cell Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Axis Elongation Androgen Metabolic Process Prostate Gland Epithelium Morphogenesis Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Prostate Gland Morphogenesis Positive Regulation Of Nitric Oxide Biosynthetic Process
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