RFX3 and AK3

		RFX3	AK3
Description		regulatory factor X3	adenylate kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Transcription Regulator Complex	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding AMP Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Ligase Activity Nucleobase-containing Compound Kinase Activity Nucleoside Triphosphate Adenylate Kinase Activity
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Cell Differentiation Endocrine Pancreas Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of Insulin Secretion Cilium Assembly Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development	Nucleobase-containing Compound Metabolic Process ADP Biosynthetic Process Blood Coagulation Nucleotide Metabolic Process Nucleoside Monophosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process AMP Metabolic Process GTP Metabolic Process ITP Metabolic Process UTP Metabolic Process
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Body mass index ( 28552196) Gout ( 25967671) Insomnia ( 29520036) Major depressive disorder ( 27479909) Monobrow thickness ( 26926045) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure in sickle cell anemia ( 24058526) Weight ( 28552196)	Crohn's disease ( 22412388) Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 27863252) Mean spheric corpuscular volume ( 32888494) Platelet count ( 20139978 22139419 26805783 29403010) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) White blood cell count ( 27863252)
Interacting Genes		13 interacting genes: BIN1 CREB1 EWSR1 FHL2 FHL3 IRF6 MEOX2 PKNOX1 RFX1 RFX4 RFX6 TRAF2 TRIP6	6 interacting genes: APPBP2 DAPK3 FBLN1 KRTAP10-8 TRIM54 ZDHHC17
Entrez ID		5991	50808
HPRD ID		03215	12439
Ensembl ID		ENSG00000080298	ENSG00000147853
Uniprot IDs		P48380	Q7Z4Y4 Q9UIJ7
PDB IDs			1ZD8 6ZJB 6ZJD 6ZJE
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Ventricular Cardiac Muscle Cell Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Nucleobase-containing Compound Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Z Disc Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Pronuclear Fusion Epithelial Cell Differentiation Cardiac Muscle Cell Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cardiac Cell Development DNA Binding Response To Cocaine Chemotaxis To Arachidonate TORC2 Complex Disassembly N-acetylneuraminate Synthase Activity N-acylneuraminate-9-phosphate Synthase Activity Pancreatic Epsilon Cell Differentiation Regulation Of Macromolecule Metabolic Process Hsp70 Protein Binding Nucleus Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Cardiac Muscle Tissue Development Sequence-specific DNA Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of Transcription By RNA Polymerase II Atrial Cardiac Muscle Cell Development Limb Development TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Nucleoside Triphosphate Adenylate Kinase Activity
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