SLC39A6 and TMEM31

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC39A6	TMEM31
Description		solute carrier family 39 member 6	transmembrane protein 31
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Lamellipodium Membrane Cell Projection Membrane Raft	Membrane
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Metal Ion Transmembrane Transporter Activity Monoatomic Cation:bicarbonate Symporter Activity	Protein Binding
	Biological Process	Epithelial To Mesenchymal Transition Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Bicarbonate Transport Metal Ion Transport Intracellular Monoatomic Cation Homeostasis Lymphocyte Activation T Cell Receptor Signaling Pathway Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane
Pathways		Zinc influx into cells by the SLC39 gene family
Drugs
Diseases
GWAS		Esophageal squamous cell cancer (length of survival) ( 23644492)
Interacting Genes		6 interacting genes: BCL2L2 MTNR1B RETREG3 SLC10A6 SPP1 TMEM31	138 interacting genes: ABHD16A ABHD5 AGPAT4 AGTRAP ANKRD46 APOD ARV1 ATP6V0C BCAP31 BLCAP BMP10 BNIP1 BTN2A2 C14orf180 C2CD2L CAMLG CCL4 CGRRF1 CLDND2 CLN5 CLRN1 CMTM7 CNIH3 COX14 COX20 CTSA CTXN3 CXCL9 CXorf66 CYB561A3 CYB5R3 DEFB103A DEFB103B DEFB105A DEFB105B DERL1 DERL3 DGAT2L6 DHRSX DNAJC30 EBP EHHADH EMP1 ERG28 FAXDC2 FCER1G FKBP8 FXYD6 GIMAP5 GJB2 GJD4 GPR151 GUCA2A GYPA HERPUD2 HIGD1C HSD17B13 HSD3B7 IFITM5 ITGAM LHFPL5 LPAR3 LRAT LY6D MALL MMP14 MS4A1 NAT8 NINJ1 NINJ2 NSDHL ORMDL2 OTOP3 OTULINL PEDS1-UBE2V1 PLN PLP1 PLP2 PMP22 PNLIPRP1 PTPN1 RDH11 REEP2 RETREG3 RNF144A RNF19B RTP2 SELENOK SELENOM SERP2 SGTA SLC30A8 SLC35E4 SLC35H1 SLC39A6 SLC41A1 SLC66A2 SLC71A2 SLC7A14 SMAGP SMIM1 SMIM3 SMPD2 SNORC SPTSSA STX12 STX5 SYNGR1 TEX264 TIMMDC1 TMBIM6 TMEM107 TMEM121 TMEM14A TMEM14C TMEM182 TMEM203 TMEM208 TMEM218 TMEM239 TMEM242 TMEM254 TMEM255B TMEM44 TMEM50A TMEM86A TMX2 TNFRSF10B TRARG1 TSPAN2 TVP23B UBE2J1 VAMP2 VAMP3 VAMP5 YIF1A YIPF6 ZFPL1
Entrez ID		25800	203562
HPRD ID		12285	06652
Ensembl ID		ENSG00000141424	ENSG00000179363
Uniprot IDs		Q13433	A0A140VK58 Q5JXX7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Sertoli Cell Proliferation Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Androgen Catabolic Process Cellular Response To Testosterone Stimulus Endoplasmic Reticulum-autophagosome Adaptor Activity Bile Acid:sodium Symporter Activity Response To 2,3,7,8-tetrachlorodibenzodioxine Substrate Localization To Autophagosome Bcl-2 Family Protein Complex Response To Macrophage Colony-stimulating Factor Regulation Of Hormone Secretion Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Positive Regulation Of Bone Resorption Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Sterol Biosynthetic Process Lipid Biosynthetic Process Response To Endoplasmic Reticulum Stress Steroid Biosynthetic Process SNAP Receptor Activity Lipid Droplet Lipid Metabolic Process Endoplasmic Reticulum Unfolded Protein Response SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Bleb Assembly Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Mitochondrial Membrane Regulation Of Retrograde Protein Transport, ER To Cytosol Organelle Membrane Fusion Cholesterol Biosynthetic Process 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Establishment Of Protein Localization To Membrane Regulation Of Cellular Localization Regulation Of Intracellular Transport Membrane Destabilizing Activity Cellular Response To Unfolded Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Sterol Metabolic Process Mitochondrial Respiratory Chain Complex Assembly Organelle Fusion Response To Unfolded Protein Regulation Of Protein Exit From Endoplasmic Reticulum Membrane Organization
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