RFC4 and RAD17

Number of citations of the paper that reports this interaction (PubMedID 11907025)
0

Data Source:
HPRD (in vitro)

		RFC4	RAD17
Description		replication factor C subunit 4	RAD17 checkpoint clamp loader component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex Elg1 RFC-like Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Rad17 RFC-like Complex Site Of Double-strand Break
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding	Nucleotide Binding Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of DNA Replication Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Regulation Of Phosphorylation Protein Localization To Site Of Double-strand Break
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		14 interacting genes: BRD4 CDK4 CEBPA CHTF18 HDAC1 PCNA PTEN RAD17 RFC2 RFC3 RFC5 RNF41 SUMO2 TRIM28	20 interacting genes: ATM ATR CLSPN CSNK1E CSNK2A1 CSNK2B HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SMG7 SNU13 USP20
Entrez ID		5984	5884
HPRD ID		00022	09124
Ensembl ID		ENSG00000163918	ENSG00000152942
Uniprot IDs		P35249	A0A0G2JP78 O75943
PDB IDs		6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ	7Z6H 8GNN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-directed DNA Polymerase Activity DNA Clamp Loader Activity Ctf18 RFC-like Complex Positive Regulation Of DNA Biosynthetic Process Single-stranded DNA Helicase Activity DNA Replication Factor C Complex Regulation Of DNA Biosynthetic Process Enzyme Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process DNA Replication Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Krueppel-associated Box Domain Binding DNA Metabolic Process DNA Damage Response Chromatin Binding DNA Repair Positive Regulation Of Catalytic Activity Cellular Response To Stress Chromosome DNA-templated DNA Replication Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Nucleus Host-mediated Suppression Of Viral Transcription Nucleic Acid Metabolic Process DNA Strand Elongation Involved In DNA Replication Regulation Of Catalytic Activity DNA Binding Host-mediated Suppression Of Viral Proces Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Strand Elongation Regulation Of Cell Cycle G2/M Phase Transition Chromatin SUMO Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Stress Regulation Of Transcription By RNA Polymerase II Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Checkpoint Clamp Complex Negative Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Macromolecule Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Mitotic DNA Integrity Checkpoint Signaling Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Histone H2AXS139 Kinase Activity DNA Strand Elongation Involved In DNA Replication Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation DNA Replication Factor C Complex DNA Replication Cellular Response To Radiation Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Double-strand Break Repair DNA-templated DNA Replication Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Homologous Recombination Nucleus Response To Radiation Recombinational Repair Positive Regulation Of DNA Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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