RFC4 and RFC2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		RFC4	RFC2
Description		replication factor C subunit 4	replication factor C subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex Elg1 RFC-like Complex	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity	DNA Replication DNA-templated DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)
Interacting Genes		14 interacting genes: BRD4 CDK4 CEBPA CHTF18 HDAC1 PCNA PTEN RAD17 RFC2 RFC3 RFC5 RNF41 SUMO2 TRIM28	14 interacting genes: CEBPA HGS KLHL20 PCNA PRKAR1A PSMA1 RAD17 RAD18 RFC1 RFC4 RFC5 SUMO2 YOD1 ZIC1
Entrez ID		5984	5982
HPRD ID		00022	02675
Ensembl ID		ENSG00000163918	ENSG00000049541
Uniprot IDs		P35249	A0A087WVY3 P35250 Q75MT5
PDB IDs		6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ	6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-directed DNA Polymerase Activity DNA Clamp Loader Activity Ctf18 RFC-like Complex Positive Regulation Of DNA Biosynthetic Process Single-stranded DNA Helicase Activity DNA Replication Factor C Complex Regulation Of DNA Biosynthetic Process Enzyme Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process DNA Replication Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Krueppel-associated Box Domain Binding DNA Metabolic Process DNA Damage Response Chromatin Binding DNA Repair Positive Regulation Of Catalytic Activity Cellular Response To Stress Chromosome DNA-templated DNA Replication Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Nucleus Host-mediated Suppression Of Viral Transcription Nucleic Acid Metabolic Process DNA Strand Elongation Involved In DNA Replication Regulation Of Catalytic Activity DNA Binding Host-mediated Suppression Of Viral Proces Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Strand Elongation Regulation Of Cell Cycle G2/M Phase Transition Chromatin SUMO Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Stress Regulation Of Transcription By RNA Polymerase II Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	DNA Clamp Loader Activity DNA Replication Factor C Complex Positive Regulation Of DNA-directed DNA Polymerase Activity Elg1 RFC-like Complex DNA Repair Macromolecule Metabolic Process DNA Replication Positive Regulation Of DNA Biosynthetic Process DNA-templated DNA Replication Ctf18 RFC-like Complex Cellular Response To Stress DNA Metabolic Process DNA Damage Response Protein Domain Specific Binding Regulation Of DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Ubiquitin Protein Ligase Binding Single-stranded DNA Helicase Activity DNA Strand Elongation Chromosome Ubiquitin-like Protein Ligase Binding Replication Fork Nucleoplasm Regulation Of Primary Metabolic Process Postreplication Repair Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process PCNA Complex Replisome Rad17 RFC-like Complex Type II Interferon Binding Rad6-Rad18 Complex Animal Organ Regeneration DNA Binding Regulation Of Catalytic Activity Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Vitamin B2 C/EBP Complex Damaged DNA Binding PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Positive Regulation Of DNA Metabolic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
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