RFC4 and CHTF18

Number of citations of the paper that reports this interaction (PubMedID 11486023)
33

Data Source:
HPRD (in vivo)

		RFC4	CHTF18
Description		replication factor C subunit 4	chromosome transmission fidelity factor 18
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex Elg1 RFC-like Complex	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Membrane Ctf18 RFC-like Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity	DNA Replication Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Polymerase switching on the C-strand of the telomere
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)	Body mass index ( 26426971) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		14 interacting genes: BRD4 CDK4 CEBPA CHTF18 HDAC1 PCNA PTEN RAD17 RFC2 RFC3 RFC5 RNF41 SUMO2 TRIM28	5 interacting genes: CRK PCNA RFC4 RFC5 STAT3
Entrez ID		5984	63922
HPRD ID		00022	13059
Ensembl ID		ENSG00000163918	ENSG00000127586
Uniprot IDs		P35249	Q8WVB6
PDB IDs		6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ	8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-directed DNA Polymerase Activity DNA Clamp Loader Activity Ctf18 RFC-like Complex Positive Regulation Of DNA Biosynthetic Process Single-stranded DNA Helicase Activity DNA Replication Factor C Complex Regulation Of DNA Biosynthetic Process Enzyme Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process DNA Replication Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Krueppel-associated Box Domain Binding DNA Metabolic Process DNA Damage Response Chromatin Binding DNA Repair Positive Regulation Of Catalytic Activity Cellular Response To Stress Chromosome DNA-templated DNA Replication Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Nucleus Host-mediated Suppression Of Viral Transcription Nucleic Acid Metabolic Process DNA Strand Elongation Involved In DNA Replication Regulation Of Catalytic Activity DNA Binding Host-mediated Suppression Of Viral Proces Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Strand Elongation Regulation Of Cell Cycle G2/M Phase Transition Chromatin SUMO Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Stress Regulation Of Transcription By RNA Polymerase II Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Positive Regulation Of DNA-directed DNA Polymerase Activity Positive Regulation Of DNA Biosynthetic Process DNA Replication Factor C Complex Enzyme Binding Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex DNA Clamp Loader Activity Regulation Of Catalytic Activity DNA Strand Elongation Involved In DNA Replication DNA Replication Single-stranded DNA Helicase Activity DNA Strand Elongation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Catalytic Activity DNA-templated DNA Replication Receptor Tyrosine Kinase Binding Response To Stress Signaling Adaptor Activity Regulation Of DNA Metabolic Process DNA Repair PCNA Complex Replisome Response To Hydrogen Peroxide Response To Estradiol Response To Hormone Regulation Of Nucleobase-containing Compound Metabolic Process Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Cerebellar Neuron Development Response To Reactive Oxygen Species DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Nucleic Acid Metabolic Process Elg1 RFC-like Complex Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation DNA Damage Response Regulation Of Response To Wounding DNA Binding Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation RNA Sequestering Activity
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