GNB4 and GNG8

Number of citations of the paper that reports this interaction (PMID 12782285)
4

Data Source:
BioGRID (pull down)

		GNB4	GNG8
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 4	guanine nucleotide binding protein (G protein), gamma 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Extracellular Vesicular Exosome	Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	Signal Transducer Activity Protein Complex Binding	GTPase Activity Signal Transducer Activity Protein Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction Substantia Nigra Development Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Nervous System Development Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport GPCR ligand binding beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		17 interactors: GNAI1 GNAI2 GNAI3 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MTNR1A MTNR1B	3 interactors: GNB1 GNB3 GNB4
Entrez ID		59345	94235
HPRD ID		09973	13593
Ensembl ID			ENSG00000167414
Uniprot IDs		Q9HAV0	Q9UK08
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Energy Reserve Metabolic Process Cell-cell Signaling Response To Peptide Hormone Cell Surface Receptor Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Cellular Response To Organonitrogen Compound Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Response To Hormone Signal Transduction Signaling Cell Communication Cellular Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Oxidation-reduction Process Response To Stimulus Cellular Response To Organic Substance Response To Organic Substance Small Molecule Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Adenylate Cyclase Activity Platelet Activation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Phototransduction Regulation Of CAMP Metabolic Process Detection Of Light Stimulus Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Body Fluid Levels Vesicle Fusion Wound Healing Cell Activation	Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Response To Hormone Oxidation-reduction Process Cellular Response To Organic Substance Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Small Molecule Metabolic Process Response To Organic Substance Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Synaptic Transmission Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Rhodopsin Mediated Signaling Pathway Cell-cell Signaling Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Fatty Acid Neural Nucleus Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Sensory Perception Of Taste Response To Fatty Acid Phototransduction, Visible Light Midbrain Development Signal Transduction Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Detection Of Light Stimulus Signaling Cellular Response To Oxygen Levels Cell Communication
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