GNG8

Description		G protein subunit gamma 8
Image		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Social Behavior Nose Development Cellular Response To Pheromone
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Crohn's disease ( 28067908)
Interacting Genes		1 interacting genes: GNB3
Entrez ID		94235
HPRD ID		13593
Ensembl ID		ENSG00000167414
Uniprot IDs		Q9UK08
PDB IDs
Enriched GO Terms of Interacting Partners?		Signaling Receptor Complex Adaptor Activity GTPase Binding Cell Volume Homeostasis Regulation Of Triglyceride Metabolic Process Regulation Of Feeding Behavior Regulation Of Phospholipid Metabolic Process Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Hormone Metabolic Process Spectrin Binding Heterotrimeric G-protein Complex Regulation Of Cholesterol Metabolic Process Regulation Of Behavior Cell Body Regulation Of Cell Size Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Regulation Of Fat Cell Differentiation Regulation Of Blood Pressure Regulation Of Cellular Component Size Regulation Of Lipid Metabolic Process GTPase Activity Regulation Of Small Molecule Metabolic Process
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