GNG8 and GNB1

Number of citations of the paper that reports this interaction (PMID 12782285)
4

Data Source:
BioGRID (pull down)

		GNG8	GNB1
Gene Name		guanine nucleotide binding protein (G protein), gamma 8	guanine nucleotide binding protein (G protein), beta polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane	Photoreceptor Inner Segment Intracellular Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Vesicle Photoreceptor Outer Segment Membrane Cell Body Extracellular Vesicular Exosome Photoreceptor Disc Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding	GTPase Activity Signal Transducer Activity Protein Binding Spectrin Binding Type 1 Angiotensin Receptor Binding Protein Complex Binding GTPase Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Nervous System Development Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Energy Reserve Metabolic Process Signal Transduction Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration G-protein Coupled Acetylcholine Receptor Signaling Pathway Ras Protein Signal Transduction Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Cell Proliferation Cardiac Muscle Cell Apoptotic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Small Molecule Metabolic Process Sensory Perception Of Taste Retina Development In Camera-type Eye Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Catecholamine Stimulus
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Olfactory Signaling Pathway Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G beta:gamma signalling through PI3Kgamma The phototransduction cascade G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Visual phototransduction Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GNB1 GNB3 GNB4	43 interactors: ADRA2A ADRB2 ADRBK1 AFP ARHGEF18 ARRB1 ATXN10 AVPR2 CACNA1A CACNA1B CACNA1C CYFIP1 DISC1 EPHA7 GNA12 GNAS GNB2L1 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 HDAC4 HDAC5 KCNJ3 MCF2 MRGPRX1 MTNR1A MTNR1B NOL11 NR3C1 PDCL PLEKHG2 PTH1R RASD1 RASD2 TBXA2R
Entrez ID		94235	2782
HPRD ID		13593	00766
Ensembl ID		ENSG00000167414	ENSG00000078369
Uniprot IDs		Q9UK08	P62873
PDB IDs			4KFM
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Response To Hormone Oxidation-reduction Process Cellular Response To Organic Substance Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Small Molecule Metabolic Process Response To Organic Substance Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Synaptic Transmission Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Rhodopsin Mediated Signaling Pathway Cell-cell Signaling Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Fatty Acid Neural Nucleus Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Sensory Perception Of Taste Response To Fatty Acid Phototransduction, Visible Light Midbrain Development Signal Transduction Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Detection Of Light Stimulus Signaling Cellular Response To Oxygen Levels Cell Communication	Cellular Response To Glucagon Stimulus Signaling Cell Communication Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Glucagon Signal Transduction Cell Surface Receptor Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Stimulus Response To Stimulus Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Synaptic Transmission Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cellular Process Response To Peptide Hormone Cell-cell Signaling Cellular Response To Organonitrogen Compound Response To Hormone Cellular Response To Organic Substance Response To Organic Substance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organonitrogen Compound Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Cyclase Activity Oxidation-reduction Process Regulation Of Muscle Contraction Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Multicellular Organismal Response To Stress Regulation Of CAMP Biosynthetic Process Platelet Activation Regulation Of Insulin Secretion Chemical Homeostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Peptide Hormone Secretion Cellular Process Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Vasoconstriction Small Molecule Metabolic Process
Tagcloud ?			abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb2 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Difference) ?			abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb2 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Intersection) ?