OS9 and EGLN1

Number of citations of the paper that reports this interaction (PMID 15721254)
40

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo)

		OS9	EGLN1
Gene Name		osteosarcoma amplified 9, endoplasmic reticulum lectin	egl-9 family hypoxia-inducible factor 1
Image
Gene Ontology Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Lumen Endoplasmic Reticulum Quality Control Compartment	Nucleus Cytoplasm Cytosol
	Molecular Function	Glycoprotein Binding Protease Binding Protein Binding Carbohydrate Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Negative Regulation Of CAMP Catabolic Process Oxygen Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Response To Nitric Oxide
Pathways		Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog	Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ACVR1B CPNE6 CREB3 DCSTAMP EGLN1 EGLN3 EIF6 FOXM1 HIF1A MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 ZNF512B	10 interactors: EPAS1 FKBP8 HIF1A HIF3A ING4 KRAS OS9 PLD1 SRC ZNF281
Entrez ID		10956	54583
HPRD ID		17804	06971
Ensembl ID		ENSG00000135506	ENSG00000135766
Uniprot IDs		B4E321 Q13438	Q9GZT9 R4SCQ0
PDB IDs		3AIH	2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4KBZ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Oxygen Levels Cellular Response To Stress Oxygen Homeostasis Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Myeloid Cell Differentiation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Regulation Of Growth Nodal Signaling Pathway Regulation Of Cell Growth Positive Regulation Of Erythrocyte Differentiation 4-hydroxyproline Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Activin Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-proline Hydroxylation Protein Hydroxylation Activin Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Myeloid Cell Differentiation Heterocycle Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus In Utero Embryonic Development Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Growth Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Cellular Macromolecular Complex Assembly Cellular Response To Stimulus Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Cortical Microtubule Organization Osmosensory Signaling Pathway Neural Fold Elevation Formation Positive Regulation Of Cellular Metabolic Process	Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Hypoxia Tube Development Response To Stress Cellular Response To Stress Tissue Remodeling Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Nitric-oxide Synthase Activity Response To Abiotic Stimulus Positive Regulation Of Monooxygenase Activity Cellular Response To Stimulus Ras Protein Signal Transduction Regulation Of Gene Expression Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Positive Regulation Of Oxidoreductase Activity Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Cell Death Stem Cell Differentiation Signaling Visual Learning Transcription From RNA Polymerase II Promoter Cell Communication Visual Behavior Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neural Fold Elevation Formation Regulation Of Transcription, DNA-templated Epithelial Tube Morphogenesis Regulation Of Oxidoreductase Activity Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cell Death Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Associative Learning Regulation Of RNA Metabolic Process Response To Interleukin-1 Response To Oxidative Stress Tube Morphogenesis Epithelium Development Mammary Gland Epithelium Development
Tagcloud ?		branch c57y calnexin calreticulin cnx constrained erad folded folding futile glc1man7glcnac2 glycan glycans glycoproteins harbours improperly interconnected kifunensine lectins mannosidases mns4 mns5 oligosaccharide sel1l sort stabilized strubbelig subex thaliana	2alpha adaptation adapted altitude another approaches basis concert encodes epas1 hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide
Tagcloud (Difference) ?		branch c57y calnexin calreticulin cnx constrained erad folded folding futile glc1man7glcnac2 glycan glycans glycoproteins harbours improperly interconnected kifunensine lectins mannosidases mns4 mns5 oligosaccharide sel1l sort stabilized strubbelig subex thaliana	2alpha adaptation adapted altitude another approaches basis concert encodes epas1 hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide
Tagcloud (Intersection) ?