OS9 and ACVR1B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		OS9	ACVR1B
Gene Name		osteosarcoma amplified 9, endoplasmic reticulum lectin	activin A receptor, type IB
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Lumen Endoplasmic Reticulum Quality Control Compartment	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Activin Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Protease Binding Protein Binding Carbohydrate Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type I Activin-activated Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding
	Biological Process	Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Central Nervous System Development Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Cell Growth Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Development Of Primary Female Sexual Characteristics Protein Autophosphorylation Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog	Signaling by Activin Regulation of signaling by NODAL Signaling by NODAL
Drugs			Adenosine triphosphate
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		16 interactors: ACVR1B CPNE6 CREB3 DCSTAMP EGLN1 EGLN3 EIF6 FOXM1 HIF1A MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 ZNF512B	20 interactors: ACVR2B BAG6 BAMBI BMPR2 FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L OS9 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TDGF1 TGFBRAP1
Entrez ID		10956	91
HPRD ID		17804	03193
Ensembl ID		ENSG00000135506	ENSG00000135503
Uniprot IDs		B4E321 Q13438	P36896
PDB IDs		3AIH
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Oxygen Levels Cellular Response To Stress Oxygen Homeostasis Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Myeloid Cell Differentiation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Regulation Of Growth Nodal Signaling Pathway Regulation Of Cell Growth Positive Regulation Of Erythrocyte Differentiation 4-hydroxyproline Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Activin Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-proline Hydroxylation Protein Hydroxylation Activin Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Myeloid Cell Differentiation Heterocycle Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus In Utero Embryonic Development Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Growth Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Cellular Macromolecular Complex Assembly Cellular Response To Stimulus Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Cortical Microtubule Organization Osmosensory Signaling Pathway Neural Fold Elevation Formation Positive Regulation Of Cellular Metabolic Process	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor SMAD Protein Signal Transduction Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Signal Transduction BMP Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cell Communication Positive Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Tissue Morphogenesis Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Mesoderm Development Regulation Of Signaling SMAD Protein Complex Assembly Heart Development Embryo Development Positive Regulation Of Phosphorylation Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		branch c57y calnexin calreticulin cnx constrained erad folded folding futile glc1man7glcnac2 glycan glycans glycoproteins harbours improperly interconnected kifunensine lectins mannosidases mns4 mns5 oligosaccharide sel1l sort stabilized strubbelig subex thaliana	125b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Difference) ?		branch c57y calnexin calreticulin cnx constrained erad folded folding futile glc1man7glcnac2 glycan glycans glycoproteins harbours improperly interconnected kifunensine lectins mannosidases mns4 mns5 oligosaccharide sel1l sort stabilized strubbelig subex thaliana	125b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Intersection) ?